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The seminal microbiome in health and disease

机译:健康和疾病中的精髓微生物组

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Owing to the fact that there are more microbial than human cells in our body and that humans contain more microbial than human genes, the microbiome has huge potential to influence human physiology, both in health and in disease. The use of next-generation sequencing technologies has helped to elucidate functional, quantitative and mechanistic aspects of the complex microorganism-host interactions that underlie human physiology and pathophysiology. The microbiome of semen is a field of increasing scientific interest, although this microbial niche is currently understudied compared with other areas of microbiome research. However, emerging evidence is beginning to indicate that the seminal microbiome has important implications for the reproductive health of men, the health of the couple and even the health of offspring, owing to transfer of microorganisms to the partner and offspring. As this field expands, further carefully designed and well-powered studies are required to unravel the true nature and role of the seminal microbiome.
机译:由于由于人体中的人体细胞具有更多的微生物并且人类含有比人类基因更多的微生物,微生物组具有影响健康和疾病的人类生理学的巨大潜力。使用下一代测序技术的使用有助于阐明具有底层人生理学和病理生理学的复杂微生物 - 宿主相互作用的功能,定量和机械方面。 Semen的微生物组是一种增加科学兴趣的领域,尽管与其他微生物组研究的其他领域相比,目前被认为是这种微生物利基。然而,新兴的证据开始表明,由于将微生物转移到合作伙伴和后代,这种精髓微生物组对男性的生殖健康,甚至是后代的健康有重要意义。随着该领域的扩展,需要进一步精心设计的和供电良好的研究来解开原创性微生物组的真正性质和作用。

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