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首页> 外文期刊>Nature reviews. Urology >Harnessing the mesenchymal stem cell secretome for regenerative urology
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Harnessing the mesenchymal stem cell secretome for regenerative urology

机译：利用间充质干细胞沉淀治疗再生泌尿外科

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The extensive arsenal of bioactive molecules secreted by mesenchymal stem cells (MSCs), known as the secretome, has demonstrated considerable therapeutic benefit in regenerative medicine. Investigation into the therapeutic potential of the secretome has enabled researchers to replicate the anti-inflammatory, pro-angiogenic and trophic effects of stem cells without the need for the cells themselves. Furthermore, treatment with the MSC secretome could circumvent hurdles associated with cellular therapy, including oncogenic transformation, immunoreactivity and cost. Thus, a clear rationale exists for investigating the therapeutic potential of the MSC secretome in regenerative urology. Indeed, preclinical studies have demonstrated the therapeutic benefits of the MSC secretome in models of stress urinary incontinence, renal disease, bladder dysfunction and erectile dysfunction. However, the specific mechanisms underpinning therapeutic activity are unclear and require further research before clinical translation. Improvements in current proteomic methods used to characterize the secretome will be necessary to provide further insight into stem cells and their secretome in regenerative urology.
机译：被间充质干细胞（MSCs）分泌的生物活性分子的广泛的砷，称为局部，在再生医学中表现出相当大的治疗益处。调查克制秘密的治疗潜力使研究人员能够复制干细胞的抗炎，促血管生成和营养效果而无需细胞本身。此外，用MSC沉淀治疗可以避免与细胞疗法相关的障碍，包括致癌转化，免疫反应性和成本。因此，存在清楚的基本原理用于研究再生泌尿外科的MSC沉淀的治疗潜力。实际上，临床前研究已经证明了MSC沉淀在压力尿失禁，肾病，膀胱功能障碍和勃起功能障碍模型中的治疗益处。然而，支撑治疗活性的特定机制尚不清楚，并且在临床翻译之前需要进一步的研究。用于表征秘密的当前蛋白质组学方法的改进是必要的，以便在再生泌尿科中进一步了解干细胞及其秘密。

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