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首页> 外文期刊>Nature reviews. Urology >Persistence and clinical relevance of Zika virus in the male genital tract.
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Persistence and clinical relevance of Zika virus in the male genital tract.

机译：Zika病毒在雄性生殖道中的持久性和临床相关性。

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摘要

Zika virus (ZIKV) is a re-emerging mosquito-transmitted flavivirus associated with congenital abnormalities in newborns and with Guillain-Barré syndrome in adults. The virus can also be sexually transmitted and can persist in the male genital tract. Studies evaluating the kinetics of ZIKV in seminal shedding of men who have been infected, as well as in animal and cellular models of infection, have shown that, in addition to the testis and epididymis, the prostate and seminal vesicles could also be involved in persistent ZIKV infection. Additionally, some studies have reported that men infected with ZIKV can present with genitourinary symptoms such as haematospermia, prostatitis, painful ejaculation, penile discharge, and oligospermia; however, little is known about the effect of ZIKV on fertility. Understanding the mechanisms that underlie persistent ZIKV infections in men is crucial to developing guidelines, effective vaccines, and therapies.
机译：Zika病毒（ZIKV）是一种重新出现的蚊虫传播的黄病毒，与新生儿的先天性异常相关，并在成人的Guillain-Barré综合征。 病毒也可以性传播并且可以持续存在于男性生殖道中。 研究评估ZIKV在已感染的男性的ZIKV动力学以及动物和细胞的感染模型中的研究表明，除了睾丸和附睾外，前列腺和精髓囊泡还可以参与持久性 ZIKV感染。 此外，一些研究报告说，感染ZIKV的男性可以呈现出饲养症状，如血红素植物，前列腺炎，痛苦的射精，阴茎放电和少血症; 然而，关于ZIKV对生育的影响很少。 了解男性持久性ZIKV感染的机制对于开发指南，有效疫苗和疗法至关重要。

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  • 来源
    《Nature reviews. Urology》 |2019年第4期|共20页
  • 作者

    Fábio A Kurscheidt; Cristiane S S Mesquita; Gabrielle M Z F Damke; Edilson Damke; Analine R B de A Carvalho; Tamy T Suehiro; Jorge J V Teixeira; Vania R S da Silva; Raquel P Souza; Marcia E L Consolaro;

  • 作者单位

    Laboratory of Clinical Cytology and Semen Analysis Department of Clinical Analysis and Biomedicine;

    Laboratory of Clinical Cytology and Semen Analysis Department of Clinical Analysis and Biomedicine;

    Laboratory of Clinical Cytology and Semen Analysis Department of Clinical Analysis and Biomedicine;

    Laboratory of Clinical Cytology and Semen Analysis Department of Clinical Analysis and Biomedicine;

    Laboratory of Clinical Cytology and Semen Analysis Department of Clinical Analysis and Biomedicine;

    Laboratory of Clinical Cytology and Semen Analysis Department of Clinical Analysis and Biomedicine;

    Division of Epidemiology Department of Clinical Analysis and Biomedicine State University of;

    Laboratory of Clinical Cytology and Semen Analysis Department of Clinical Analysis and Biomedicine;

    Laboratory of Clinical Cytology and Semen Analysis Department of Clinical Analysis and Biomedicine;

    Laboratory of Clinical Cytology and Semen Analysis Department of Clinical Analysis and Biomedicine;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 泌尿科学（泌尿生殖系疾病）;
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