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Managing high-grade prostatic intraepithelial neoplasia (HGPIN) and atypical glands on prostate biopsy

机译:在前列腺活检中管理高级前列腺上皮内瘤形成(HGPIN)和非典型腺体

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摘要

Prostate biopsy is the gold standard for diagnosing prostate cancer and reliable pathological assessment is essential for guiding management. Research efforts over the past few years have aimed to establish a more universal approach to management according to pathological grading; however, high-grade prostatic intraepithelial neoplasia (HGPIN) and atypical glands suspicious for carcinoma are two diagnoses without standardized follow-up and treatment pathways. Much of this uncertainty is due to limited evidence describing the subsequent rates of cancer and high-grade cancer when HGPIN or atypical glands are detected on initial biopsy. Fortunately, data from the past decade have shed light on these phenomena, and an improved understanding of the implications of the presence of HGPIN and atypical glands on prostate biopsy means that clinical recommendations can be made for the management of patients with these diagnoses.
机译:前列腺活检是诊断前列腺癌的金标准,可靠的病理评估对于指导管理至关重要。 过去几年的研究努力旨在根据病理分级建立更普遍的管理方法; 然而,高级前列腺上皮内瘤形成(HGPIN)和癌症的非典型腺体在没有标准化后续和治疗途径的情况下是两种诊断。 许多这种不确定性是由于在初始活组织检查在初始活检时检测到HGPIN或非典型腺体后随后的癌症和高级癌症的证据是有限的。 幸运的是,来自过去十年的数据对这些现象具有揭示,并且改善了对前列腺活检的影响和非典型腺体的影响意味着可以对这些诊断的患者进行临床建议。

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  • 来源
    《Nature reviews. Urology》 |2018年第1期|共12页
  • 作者单位

    Johns Hopkins Univ Sch Med Dept Urol James Buchanan Brady Urol Inst 600 N Wolfe St Marburg 134;

    Johns Hopkins Univ Sch Med Dept Urol James Buchanan Brady Urol Inst 600 N Wolfe St Marburg 134;

    Johns Hopkins Univ Sch Med Dept Urol James Buchanan Brady Urol Inst 600 N Wolfe St Marburg 134;

    Johns Hopkins Univ Sch Med Dept Urol James Buchanan Brady Urol Inst 600 N Wolfe St Marburg 134;

    Johns Hopkins Univ Dept Pathol Sch Med 401 N Broadway Weinberg 2242 Baltimore MD 21231 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 泌尿科学(泌尿生殖系疾病);
  • 关键词

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