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An interdisciplinary consensus on the management of bone metastases from renal cell carcinoma

机译：关于肾细胞癌骨转移管理的跨学科共识

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Bone is a major site of haematogenous tumour cell spread in renal cell carcinoma (RCC), and most patients with RCC will develop painful and functionally disabling bone metastases at advanced disease stages. The prognosis of these patients is generally poor and the treatment is, therefore, aimed at palliation. However, RCC-associated bone metastases can be curable in select patients. Current data support a multimodal management strategy that includes wide resection of lesions, radiotherapy, systemic therapy, and other local treatment options, which can improve quality of life and survival. Nevertheless, the optimal approach for metastatic bone disease in RCC has not yet been defined and practical recommendations are rare. To improve the management and outcomes of patients with RCC and bone metastases, the International Kidney Cancer Coalition and the interdisciplinary working group on renal tumours of the German Cancer Society convened a meeting of experts with a global perspective to perform an unstructured review and elaborate on current treatment strategies on the basis of published data and expertise. The panel formulated recommendations for the diagnosis and treatment of patients with RCC and metastasis to the bone. Furthermore, the experts summarized current challenges and unmet patient needs that should be addressed in the future.
机译：骨骼是肾细胞癌（RCC）扩散的血液肿瘤细胞的主要部位，大多数RCC患者将在晚期疾病阶段开发疼痛和功能致残的骨转移。这些患者的预后通常差，因此，旨在对粘连的治疗。然而，可以在选择患者中可以固化rcc相关的骨转移。目前的数据支持多峰管理策略，包括广泛切除病变，放疗，全身疗法和其他局部治疗方案，这可以提高生活质量和生存。然而，RCC中转移性骨病的最佳方法尚未确定，并且实际的建议是罕见的。为了改善RCC和骨转移患者的管理和结果，德国癌症协会肾脏肿瘤的国际肾癌联盟和跨学科工作组召开了一个专家会议，全球视角召开了一个非结构化的审查和精心制定的在公布的数据和专业知识的基础上处理策略。该小组制定了诊断和治疗RCC和转移到骨骼患者的建议。此外，专家概述了当前应在未来解决的挑战和未满足的患者需求。

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