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首页> 外文期刊>Neoplasma: Journal of Experimental and Clinical Oncology >Concurrent hyperthermia and re-irradiation for recurrent high-grade gliomas
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Concurrent hyperthermia and re-irradiation for recurrent high-grade gliomas

机译：并发热疗和再辐射复发性高级胶质瘤

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摘要

Salvage therapy for recurrent high grade gliomas (HGG) includes surgery, radiotherapy and chemotherapy, however, standard treatment does not exist. We evaluated the tolerability and efficacy of re-irradiation (re-RT) with hyperthermia (HT) for patients with recurrent HGG. From September 2010 to July 2015, 20 patients with recurrent HGG were treated with re-RT and HT. The radiotherapy dose of 30 Gray (Gy) was delivered with 2 Gy per fraction daily, and HT was performed twice weekly. Primary endpoints were treatment compliance and toxicity. Second endpoints were overall survival (OS) and progression free survival (PFS). The median interval between initial RT and re-RT was 11 months. During re-RT with HT, there were no significant acute morbidities over grade 3. Median overall survival (OS) from re-irradiation was 8.4 months and the 6 and 12 months survival rate were 67% and 30%, respectively. The median progression free survival (PFS) from re-irradiation was 4.1 month. Our findings suggested that concurrent re-RT with HT was a safe and well-tolerated. In addition, the combination re-RT and HT could be a valuable salvage treatment option for selected recurrent HGG patients with poor performance status.
机译：用于复发性高级胶质瘤（HGG）的救助治疗包括手术，放疗和化疗，然而，标准治疗不存在。我们评估了重新辐照（RT）对复发性HGG患者的热疗（RT）对再辐射（RT）的耐受性和功效。 2010年9月至2015年7月，20例复发性HGG患者接受了RT RT和HT。 30灰色（GY）的放射疗法剂量每天每次分数递送2 GY，每周一次进行两次。主要终点是治疗顺应性和毒性。第二个终点是整体存活（OS）和进展免费存活（PFS）。初始RT和RT-RT之间的中值间隔为11个月。在RT与HT期间，在3年级中没有显着的急性生命条件3.中位数存活（OS）从重新辐射中为8.4个月，6和12个月的存活率分别为67％和30％。重新辐射中位进展免费生存（PFS）为4.1个月。我们的研究结果表明，随着HT的并发RT是安全且耐受的。此外，组合RT和HT可以是具有差的性能状况不佳的复发性HGG患者的有价值的救助治疗选择。

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