Model systems for analysis of dopamine transporter function and regulation

Hovde Moriah J.; Larson Garret H.; Vaughan Roxanne A.; Foster James D.

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Model systems for analysis of dopamine transporter function and regulation

机译：多巴胺运输函数和调节分析模型系统

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The dopamine transporter (DAT) plays a critical role in dopamine (DA) homeostasis by clearing transmitter from the extraneuronal space after vesicular release. DAT serves as a site of action for a variety of addictive and therapeutic reuptake inhibitors, and transport dysfunction is associated with transmitter imbalances in disorders such as schizophrenia, attention deficit hyperactive disorder, bipolar disorder, and Parkinson disease. In this review, we describe some of the model systems that have been used for in vitro analyses of DAT structure, function and regulation, and discuss a potential relationship between transporter kinetic values and membrane cholesterol.

机译：多巴胺转运蛋白（DAT）通过在囊泡释放后从肌内空间中清除发射器来发挥关键作用。 DAT作为各种上瘾和治疗性再摄取抑制剂的动作部位，并且运输功能障碍与疾病的发射器失衡相关，例如精神分裂症，注意力过度活跃障碍，双相障碍和帕金森病。在该综述中，我们描述了用于体外分析的DAT结构，功能和调节的一些模型系统，并讨论转运蛋白值与膜胆固醇之间的潜在关系。

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《Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry》 |2019年第2019期|共9页
作者
Hovde Moriah J.; Larson Garret H.; Vaughan Roxanne A.; Foster James D.;
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作者单位

Univ North Dakota Sch Med &

Hlth Sci Dept Biomed Sci Grand Forks ND 58202 USA;

Univ North Dakota Sch Med &

Hlth Sci Dept Biomed Sci Grand Forks ND 58202 USA;

Univ North Dakota Sch Med &

Hlth Sci Dept Biomed Sci Grand Forks ND 58202 USA;

Univ North Dakota Sch Med &

Hlth Sci Dept Biomed Sci Grand Forks ND 58202 USA;

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正文语种 eng
中图分类生物化学;
关键词
Kinetic parameters; Neuronal cultures; CFT; Cholesterol; Striatum; Nucleus accumbens;

机译：动力学参数;神经元培养;CFT;胆固醇;纹状体;核心腺;

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1. Model systems for analysis of dopamine transporter function and regulation [J] . Hovde Moriah J., Larson Garret H., Vaughan Roxanne A., Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry . 2019,第期

机译：多巴胺运输函数和调节分析模型系统
2. Regulation of dopamine transporter function and plasma membrane expression by dopamine, amphetamine, and cocaine. [J] . Kahlig KM, Galli A European Journal of Pharmacology: An International Journal . 2003,第1a3期

机译：多巴胺，苯丙胺和可卡因对多巴胺转运蛋白功能和质膜表达的调节。
3. The SLC6 transporters: Perspectives on structure, functions, regulation, and models for transporter dysfunction [J] . RudnickG., Kr?merR., BlakelyR.D., Pfluegers Archiv: European Journal of Physiology . 2014,第1期

机译：SLC6转运蛋白：关于转运蛋白功能障碍的结构，功能，调控和模型的观点
4. Structure-function relationships of the di/tri-peptide transporter of the yeast Saccharomyces cerevisiae:a model system for studying substrate recognition and regulation of membrane proteins involved in peptide transport [C] . Jeffrey M.Becker, Melinda Hauser, Steven Minkin International Peptide Symposium;European Peptide Symposium . 2005

机译：酵母酿酒酵母的DI /三肽转运蛋白的结构函数关系：一种研究底物识别的模型系统和肽运输中膜蛋白的调节
5. Structure/function studies of membrane proteins: From molecular modeling and ligand binding to protein -protein interactions of the dopamine transporter [D] . Beuming, Thijs. 2007

机译：膜蛋白的结构/功能研究：从分子模型和配体结合到多巴胺转运蛋白的蛋白-蛋白相互作用
6. Hippocampal dysfunction and disruption of dopamine system regulation in an animal model of schizophrenia [O] . Daniel J. Lodge, Anthony A. Grace -1

机译：精神分裂症动物模型中的海马功能障碍和多巴胺系统调节的破坏
7. Model systems for analysis of dopamine transporter function and regulation [O] . Moriah J. Hovde, Garret H. Larson, Roxanne A. Vaughan, 2019

机译：多巴胺运输函数和调节分析模型系统

Model systems for analysis of dopamine transporter function and regulation

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