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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Alpha-lipoic acid attenuates acute neuroinflammation and long-term cognitive impairment after polymicrobial sepsis
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Alpha-lipoic acid attenuates acute neuroinflammation and long-term cognitive impairment after polymicrobial sepsis

机译：α-硫辛酸在多发性败血症后衰减急性神经炎症和长期认知障碍

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摘要

Sepsis is a complication of an infection which imbalance the normal regulation of several organ systems, including the central nervous system (CNS). Evidence points towards inflammation and oxidative stress as major steps associated with brain dysfunction in sepsis. Thus, we investigated the alpha-lipoic acid (ALA) effect as an important antioxidant compound on brain dysfunction in rats. Wistar rats were subjected to sepsis by cecal ligation and perforation (CLP) or sham (control) and treated orally with ALA (200 mg/kg after CLP) or vehicle. Animals were divided into sham + saline, sham + ALA, CLP + saline and CLP + ALA groups. Twelve, 24 h and 10 days after surgery, the hippocampus, prefrontal cortex and cortex were obtained and assayed for levels of TNF-alpha and IL-1 beta, blood brain barrier (BBB) permeability, nitrite/nitrate concentration, myeloperoxidase (MPO) activity, thiobarbituric acid reactive species (TBARS) formation, protein carbonyls, superoxide dismutase (SOD) and catalase (CAT) activity and neurotrophins levels. Behavioral tasks were performed 10 days after surgery. ALA reduced BBB permeability and TNF-alpha levels in hippocampus in 24 h and IL-1 beta levels and MPO activity in hippocampus and prefrontal cortex in 24 h. ALA reduced nitrite/nitrate concentration and lipid peroxidation in 24 h in all structures and protein carbonylation in 12 and 24 h in hippocampus and cortex. CAT activity increased in the hippocampus and cortex in all times. ALA enhanced NGF levels in hippocampus and cortex and prevented cognitive impairment. Our data demonstrates that ALA reduces the consequences of polymicrobial sepsis in rats by decreasing inflammatory and oxidative stress parameters in the brain. (C) 2017 Published by Elsevier Ltd.
机译：败血症是一种感染的并发症，其失衡了几种器官系统的正常调节，包括中枢神经系统（CNS）。证据表明炎症和氧化应激作为与败血症中脑功能障碍相关的主要步骤。因此，我们将α-硫辛酸（ALA）效应作为大鼠脑功能障碍的重要抗氧化剂效应。通过肠连接和穿孔（CLP）或假（对照）对Wistar大鼠进行脓毒症，并用Ala（CLP之后200mg / kg）或载体口服处理。将动物分成假+盐水，假+ Ala，CLP +盐水和CLP + ALA组。在手术后，24小时和10天，获得海马，前额叶皮质和皮质，并测定TNF-α和IL-1β的水平，血脑屏障（BBB）渗透率，亚硝酸盐/硝酸盐浓度，髓过氧​​化物酶（MPO）活性，硫氨基甲酸反应性物质（TBARS）形成，蛋白质羰基，超氧化物歧化酶（SOD）和过氧化氢酶（猫）活性和神经营养素水平。手术后10天进行行为任务。 ALA在24小时和IL-1β水平和IL-1β水平和24小时的前额叶皮质中降低了海马和IL-1β水平和MPO活性的BBB渗透性和TNF-α水平。在海马和皮质的所有结构和蛋白质羰基化中，在24小时内将亚硝酸盐/硝酸盐浓度和脂质过氧化降低。猫活性在海马和皮质中增加。 ALA增强了海马和皮质的NGF水平，并阻止了认知障碍。我们的数据表明，ALA通过降低大脑中的炎症和氧化应激参数来减少多发性脓毒症在大鼠中的后果。 （c）2017年由elestvier有限公司出版

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