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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Mitophagy in neurodegeneration and aging
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Mitophagy in neurodegeneration and aging

机译：神经变性和老化中的水墨

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Abstract Mitochondrial dysfunction contributes to normal aging and a wide spectrum of age-related diseases, including neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease. It is important to maintain a healthy mitochondrial population which is tightly regulated by proteolysis and mitophagy. Mitophagy is a specialized form of autophagy that regulates the turnover of damaged and dysfunctional mitochondria, organelles that function in producing energy for the cell in the form of ATP and regulating energy homeostasis. Mechanistic studies on mitophagy across species highlight a sophisticated and integrated cellular network that regulates the degradation of mitochondria. Strategies directed at maintaining a healthy mitophagy level in aged individuals might have beneficial effects. In this review, we provide an updated mechanistic overview of mitophagy pathways and discuss the role of reduced mitophagy in neurodegeneration. We also highlight potential translational applications of mitophagy-inducing compounds, such as NAD + precursors and urolithins. Highlights ? Mitophagy is essential for the maintenance of mitochondrial quality in neurons. ? Compromised autophagy/mitophagy can cause neurodegenerative diseases. ? Different molecular pathways of mitophagy have been uncovered. ? Mitophagy induction can be a novel approach for the treatment of some neurodegenerative diseases.
机译：摘要线粒体功能障碍有助于正常老化和广泛的年龄相关疾病，包括神经变性疾病，如帕金森病和阿尔茨海默病。保持健康的线粒体种群是非常重要的，该人群受到蛋白水解和乳化物的紧密调节。 MITophagy是一种专业形式的自噬形式，调节受损和功能障碍线粒体的营业额，其功能细胞器，其在为ATP和调节能量稳态的形式产生细胞的能量。跨物种乳化物的机械研究突出了调节线粒体降解的复杂和综合的细胞网络。针对老年人维持健康的炸药水平的策略可能具有有益的效果。在本综述中，我们提供了MICOPGAY途径的更新机制概述，并讨论了减少的乳化物在神经变性中的作用。我们还突出了诱导细菌诱导化合物的潜在平移应用，例如NAD +前体和尿道。强调 ？ MINOPGAGY对于在神经元中维持线粒体质量至关重要。还受损的自噬/ mitophagy会导致神经变性疾病。还已经发现了不同的分子量的乳化物途径。还细菌诱导可以是治疗一些神经变性疾病的新方法。

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