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首页> 外文期刊>Neurobiology of learning and memory >Neural Coding of Appetitive Food Experiences in the Amygdala
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Neural Coding of Appetitive Food Experiences in the Amygdala

机译：Amygdala在amygdala的性食物经验的神经编码

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Real-life experiences involve the consumption of various foods, yet it is unclear how the brain distinguishes and categorizes such food experiences. Despite the crucial roles of the basolateral amygdala (BLA) in appetitive behavior and emotion, how BLA pyramidal cells and interneurons encode food experiences has not yet been well characterized. Here we employ large-scale tetrode recording techniques to investigate the coding properties of pyramidal neurons vs. fast-spiking interneurons in the BLA as mice freely consumed a variety of foods, such as biscuits, rice, milk and water. We found that putative pyramidal cells conformed to the power-of-two-based permutation logic, as postulated by the Theory of Connectivity, to generate specific-to-general neural clique coding patterns. Many pyramidal cells exhibited firing increases specific to a given food type, while some other pyramidal cells increased firings to various combinations of multiple foods. In contrast, fast-spiking interneurons can increase or decrease firings to given food types, and were more broadly tuned to various food experiences. We further show that a subset of pyramidal cells exhibited rapid desensitization to repeated eating of the same food, correlated with rapid behavioral habituation. Finally, we provide the intuitive visualization of BLA ensemble activation patterns using the dimensionality-reduction classification method to decode real-time appetitive stimulus identity on a moment-to-moment, single trial basis. Elucidation of the neural coding patterns in the BLA provides a key insight into how the brain's emotion and memory circuits performs the computational operation of pattern discrimination and categorization of natural food experiences.
机译：现实生活经验涉及各种食物的消费，但目前尚不清楚大脑如何区分和分类这些食物经验。尽管基石运动Amygdala（BLA）在快速行为和情绪中，BLA金字塔细胞和中间核算尚未充分的表征尚未得到很好的表现。在这里，我们采用大规模的四码记录技术来研究金字塔神经元的编码特性与BLA中的快速尖峰间的性质，因为小鼠自由地消耗了各种食物，如饼干，米饭，牛奶和水。我们发现推定的金字塔型细胞符合两种基于动力的置换逻辑，通过连接理论假设，产生特定的神经集合编码模式。许多金字塔细胞表现出对给定食物类型特异的烧制增加，而一些其他金字塔细胞对多种食物的各种组合增加了一些。相比之下，快速尖峰的型细胞源可以增加或减少给予食物类型的烧制，并且更广泛地调整各种食物经历。我们进一步表明，金字塔细胞的子集表现出快速脱敏，重复进食相同的食物，与快速行为习性相关。最后，我们使用维度减少分类方法提供了BLA集合激活模式的直观可视化，以在瞬间，单次试验基础上解码实时满意刺激标识。 BLA中神经编码模式的阐明提供了对大脑的情绪和内存电路如何执行模式辨别和自然食品经验的分类的计算操作的关键洞察。

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