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首页> 外文期刊>Neurobiology of learning and memory >Aerobic exercise upregulates the BDNF-Serotonin systems and improves the cognitive function in rats
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Aerobic exercise upregulates the BDNF-Serotonin systems and improves the cognitive function in rats

机译：有氧运动上调BDNF-血清素系统，并改善了大鼠的认知功能

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Aerobic exercise (AE) benefits brain health and behavior. Serotonin (5-HT) and brain-derived neurotrophic factor (BDNF) are known to mediate and shape cognitive processes. Both systems share some actions: BDNF is involved in the maturation and function of 5-HT neurons. In turn, 5-HT is involved in neuroplasticity phenomena mediated by BDNF and stimulated by exercise. The aim of this work was to study the long-term effects of AE on BDNF- 5-HT systems and cognitive function in rats at different ages. A lifelong moderate-intensity aerobic training program was designed, in which aerobically exercised (E) and sedentary control (C) rats were studied at middle (8 months) and old age (18 months) by means of biochemical, immunohistochemical and behavioral assays. The levels and expression of BDNF, 5-HT, serotonin transporter (SERT) and 5-HT1A receptor were determined in selected brain areas involved in memory and learning. Immunopositive cells to neuronal nuclear protein (NeuN) in the hippocampus CA1 area were also quantified. The cognitive function was evaluated by the object recognition test (ORT). Results indicate that AE enhanced spatial and non-spatial memory systems, modulated by age. This outcome temporarily correlated with a significant upregulation of cortical, hippocampal and striatal BDNF levels in parallel with an increase in the number of hippocampal CA1-mature neurons. AE also increased brain and raphe 5-HT levels, as well as the expression of SERT and 5-HT1A receptor in the cortex and hippocampus. Old AE rats showed a highly conserved response, indicating a remarkable protective effect of exercise on both systems. In summary, lifelong AE positively affects BDNF-5-HT systems, improves cognitive function and protects the brain against the deleterious effects of sedentary life and aging.
机译：有氧运动（AE）有益于脑健康和行为。已知血清素（5-HT）和脑衍生的神经营养因子（BDNF）介导和形状认知过程。两个系统都分享了一些动作：BDNF参与了5-HT神经元的成熟和功能。反过来，5-HT参与由BDNF介导的神经塑性现象，并通过运动刺激。这项工作的目的是研究AE对不同年龄大鼠BDNF-5-HT系统和认知功能的长期影响。设计了终身中等强度的有氧培训计划，其中通过生化，免疫组织化学和行为测定，在中间（8个月）和老年龄（18个月）和老年龄（18个月）中进行有氧运动（e）和久坐的对照（c）大鼠。 BDNF，5-HT，血清素转运蛋白转运蛋白（SERT）和5-HT1A受体的水平和表达在参与记忆和学习的选定脑区域中测定。还量化了海马CA1面积中的神经元核蛋白（Neun）的免疫阳性细胞。通过对象识别测试（ORT）评估认知功能。结果表明AE增强的空间和非空间存储器系统，按年龄调制。这一结果暂时与皮质，海马和纹状体BDNF水平的显着上调，与海马CA1-成熟神经元数的增加并行。 AE也增加了大脑和拉斐尔5-HT水平，以及皮质和海马中的SERT和5-HT1A受体的表达。老AE大鼠表现出高度保守的反应，表明运动对两个系统的显着保护作用。总之，Lifelong AE积极影响BDNF-5-HT系统，改善认知功能并保护大脑免受久坐生活和老化的有害影响。

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