Molecular mechanisms controlling protein synthesis in memory reconsolidation

Roesler Rafael

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Molecular mechanisms controlling protein synthesis in memory reconsolidation

机译：控制蛋白质合成在记忆重新溶解中的分子机制

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It is currently well established that the synthesis of new proteins (mRNA translation) is required for longlasting synaptic plasticity and memory formation. Translation in the brain is regulated primarily at the initiation stage by general as well as by gene-specific mechanisms. Stored memories can become sensitive to interference upon reactivation, through a process termed reconsolidation, which depends on protein synthesis. Here, I examine the role of translation control mechanisms, focusing particularly on the mechanistic target of rapamycin complex 1 (mTORC1), in reconsolidation. (C) 2017 Elsevier Inc. All rights reserved.

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《Neurobiology of learning and memory》 |2017年第1期|共11页
作者
Roesler Rafael;
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作者单位

Univ Fed Rio Grande do Sul Inst Basic Hlth Sci Dept Pharmacol BR-90050170 Porto Alegre RS;

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原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词
Protein synthesis; Translation control; Rapamycin Mechanistic target of rapamycin; Fear memory; Memory reconsolidation;

机译：蛋白质合成;翻译控制;雷帕霉素的雷帕霉素机械靶标;恐惧记忆;记忆重新源;

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1. Molecular mechanisms controlling protein synthesis in memory reconsolidation [J] . Roesler Rafael Neurobiology of learning and memory . 2017,第Pta1期

机译：控制蛋白质合成在记忆重新溶解中的分子机制
2. Phase-dependent molecular requirements for memory reconsolidation: differential roles for protein synthesis and protein kinase A activity. [J] . Kemenes G, Kemenes I, Michel M, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2006,第23期

机译：记忆重建的阶段依赖性分子要求：蛋白质合成和蛋白质激酶A活性的不同作用。
3. Signaling Pathways and Molecular Mechanisms through which Branched-Chain Amino Acids Mediate Translational Control of Protein Synthesis [J] . Scot R. Kimball*, Leonard S. Jefferson*4 The Journal of Nutrition: Official Organ of the American Institute of Nutrition . 2006,第1期

机译：支链氨基酸介导蛋白质合成翻译控制的信号通路和分子机制
4. In-Silico Structural Analysis of SoxF Protein Through Molecular Modelling and Protein-Protein Docking from Hydrogenophilus thermoluteolus: An Approach to Understand the Molecular Mechanism of Thiosulfate Oxidation [C] . Sujay Ray, Angshuman Bagchi International Conference on Information Systems Design and Intelligence Applications . 2015

机译：SOXF蛋白通过分子建模和蛋白质 - 蛋白蛋白对催泪蛋白的硅蛋白质结构分析：一种了解硫代硫酸盐氧化分子机制的方法
5. Intracellular mechanisms of cocaine-memory reconsolidation in the basolateral amygdala and dorsal hippocampus. [D] . Wells, Audrey Marie. 2013

机译：基底外侧杏仁核和背侧海马中可卡因记忆再整合的细胞内机制。
6. Phase-Dependent Molecular Requirements for Memory Reconsolidation: Differential Roles for Protein Synthesis and Protein Kinase A Activity [O] . György Kemenes, Ildikó Kemenes, Maximilian Michel, 2006

机译：记忆重建的相位依赖的分子要求：蛋白质合成和蛋白质激酶A活性的不同作用。
7. Phase-dependent molecular requirements for memory reconsolidation: differential roles for protein synthesis and protein kinase A activity [O] . Kemenes, György, Kemenes, Ildikó, Michel, Maximilian, 2006

机译：记忆重建的相依赖分子要求：蛋白质合成和蛋白激酶a活性的差异作用
8. Molecular Mechanisms of Steroid Hormone Action: An Examination of Relationships Between Rates of Synthesis of Individual Proteins and the Generation of Metabolic and Lethal Actions of Glucocorticoid Hormones in Lymphoid Cells [R] . Voris, B. P. 1981

机译：类固醇激素作用的分子机制：检测单个蛋白质的合成速率与淋巴细胞中糖皮质激素的代谢和致死作用的关系

Molecular mechanisms controlling protein synthesis in memory reconsolidation

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