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首页> 外文期刊>Neurobiology of learning and memory >Consolidation and reconsolidation are impaired by oral propranolol administered before but not after memory (re)activation in humans
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Consolidation and reconsolidation are impaired by oral propranolol administered before but not after memory (re)activation in humans

机译：通过在人类中施用的口服丙醇醇损害整合和重新溶解，但在人类中的记忆（重新）激活之后

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Propranolol administered immediately after learning or after recall has been found to impair memory consolidation or reconsolidation (respectively) in animals, but less reliably so in humans. Since reconsolidation impairment has been proposed as a treatment for mental disorders that have at their core an emotional memory, it is desirable to understand how to reliably reduce the strength of pathogenic memories in humans. We postulated that since humans (unlike experimental animals) typically receive propranolol orally, this introduces a delay before this drug can exert its memory impairment effects, which may render it less effective. As a means to test this, in two double-blind placebo-controlled experiments, we examined the capacity of propranolol to impair consolidation and reconsolidation as a function of timing of ingestion in healthy subjects. In Experiment 1, (n = 36), propranolol administered immediately after learning or recall failed to impair the consolidation or reconsolidation of the memory of a standardized slideshow with an accompanying emotional story. In Experiment 2 (n = 50), propranolol given 60-75 min before learning or recall successfully impaired memory consolidation and reconsolidation. These results suggest that it is possible to achieve reliable memory impairment in humans if propranolol is given before learning or before recall, but not after. (C) 2016 Elsevier Inc. All rights reserved.
机译：学习后立即或召回后立即给予proPranolol，以召回在动物中损害记忆整合或重新垄断（分别），但在人类中较不可能可靠。由于重新垄断损害已经提出为在其核心处于情绪记忆的精神障碍的治疗中，因此希望了解如何可靠地降低人类致病记忆的强度。我们假设从人类（与实验动物不同）通常会在口服接受丙醇罗酚，这引入了这种药物可以发挥其记忆损伤效果之前的延迟，这可能会使它不太有效。作为测试这一点的手段，在两个双盲安慰剂对照实验中，我们检查了普萘洛尔损​​害整合和重新源性的能力，作为健康受试者的摄入时机的函数。在实验1中，（n = 36），学习或召回后立即施用的丙醇醇未能损害与随附的情绪故事的标准化幻灯片的核心的整合或重新垄断。在实验2（n = 50）中，在学习之前给予60-75分钟的普萘洛尔，或者回忆成功受损的记忆合并和重新垄断。这些结果表明，如果在学习之前或在召回之前给出ProPranolol，则可以在人类中获得可靠的内存损伤，但在召回之前，但不是之后。 （c）2016年Elsevier Inc.保留所有权利。

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