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首页> 外文期刊>Neurobiology of learning and memory >Learning and memory is modulated by cannabidiol when administered during trace fear-conditioning
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Learning and memory is modulated by cannabidiol when administered during trace fear-conditioning

机译：在痕量恐惧调节期间施用时，大麻吡啶醇调节学习和记忆

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Cannabidiol (CBD) is thought to have therapeutic potential for treating psychiatric conditions that affect cognitive aspects of learning and memory, including anxiety and post-traumatic stress disorder (PTSD). Studies have shown that CBD enhances extinction of fear memory when given after conditioning. This led us to hypothesize that CBD, if administered prior to fear conditioning, might modulate cognitive learning and memory processes in additional ways that would further guide its potential use for treating PTSD. Therefore, we designed a study to investigate effects of CBD on fear learning and memory when administered to mice prior to administering a trace fear conditioning protocol which imposes cognitive demands on the learning and memory process. We show that CBD-treated animals had increased levels of freezing during conditioning, enhanced generalized fear, inhibited cue-dependent memory extinction, slightly increased levels of freezing during an auditory-cued memory test, and increased contextual fear memory. Because synaptic plasticity is the fundamental mechanism of learning and memory, we also evaluated the impact of CBD on trace conditioning-dependent dendritic spine plasticity which occurred in the dorsal lateral amygdala and CAl region of the ventral hippocampus. We showed that CBD mildly enhanced spine densities independent of conditioning, and inhibited conditioning-dependent spine increases in the hippocampi, but not the amygdala of fear conditioned animals. Overall, the memory-modulating effects of a single pre-conditioning dose of CBD, which we show here, demonstrate the need to more fully characterize its basic effects on memory, suggest caution when using it clinically as an anxiolytic, and point to a need for more research into its potential as a therapeutic for treating memory-loss disorders.
机译：Cannabidiol（CBD）被认为具有治疗影响学习和记忆的认知方面的精神疾病的治疗潜力，包括焦虑和创伤后应激障碍（PTSD）。研究表明，CBD在调理后给予恐惧记忆的消失。这导致我们假设CBD，如果在恐惧调理之前给药，可能会以额外的方式调制认知学习和记忆过程，这将进一步指导其用于治疗PTSD的潜在用途。因此，我们设计了研究CBD在给予小鼠之前探讨CBD对恐惧学习和记忆的影响，在给予小鼠之前给予小鼠，这对学习和记忆过程产生认知需求。我们表明，CBD处理的动物在调理过程中冻结的水平增加，增强的广义恐惧，抑制了依赖性的记忆灭绝，在听觉抑制的记忆试验中略微增加，冻结水平，增加了语境恐惧记忆。由于突触可塑性是学习和记忆的基本机制，我们还评估了CBD对腹侧海马背侧杏仁菌和Cal区的痕量条件依赖性树突脊柱塑性的影响。我们表明，海马，抑制依赖于调理的CBD温和增强的脊柱密度，但在海马中增加，但不是恐惧条件的Amygdala。总体而言，我们在此显示的单一预调节剂量的CBD的记忆调节效应证明了需要更充分地表征其对记忆的基本影响，建议在临床上用作抗焦虑时，并指向需要对于患者作为治疗记忆丧失障碍的治疗性的更多研究。

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