...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neurobiology of learning and memory >Adult hippocampal MeCP2 preserves the genomic responsiveness to learning required for long-term memory formation
【24h】

Adult hippocampal MeCP2 preserves the genomic responsiveness to learning required for long-term memory formation

机译：成人海马MECP2保留了长期记忆形成所需的学习基因组响应性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

MeCP2 is required both during postnatal neurodevelopment and throughout the adult life for brain function. Although it is well accepted that MeCP2 in the maturing nervous system is critical for establishing normal development, the functions of MeCP2 during adulthood are poorly understood. Particularly, the requirement of hippocampal MeCP2 for cognitive abilities in the adult is not studied. To characterize the role of MeCP2 in adult neuronal function and cognition, we used a temporal and region-specific disruption of MeCP2 expression in the hippocampus of adult male mice. We found that MeCP2 is required for long-term memory formation and that it controls the learning-induced transcriptional response of hippocampal neurons required for memory consolidation. Furthermore, we uncovered MeCP2 functions in the adult hippocampus that may underlie cognitive integrity. We showed that MeCP2 maintains the developmentally established chromatin configuration and epigenetic landscape of CA1 neurons throughout the adulthood, and that it regulates the expression of neuronal and immune-related genes in the adult hippocampus. Overall, our findings identify MeCP2 as a maintenance factor in the adult hippocampus that preserves signal responsiveness of the genome and allows for integrity of cognitive functions. This study provides new insight into how MeCP2 maintains adult brain functions, but also into the mechanisms underlying the cognitive impairments observed in RTT patients and highlights the understudied role of DNA methylation interpretation in adult cognitive processes.
机译：在产后神经发育期间和整个成年生命中需要MECP2，用于脑功能。虽然很好的是，MECP2在成熟的神经系统中对于建立正常发展至关重要，但是在成年期间MECP2的功能很差。特别是，没有研究成人中的认知能力的海马MECP2的要求。为了表征MECP2在成人神经元功能和认知中的作用，我们使用了成年雄性小鼠海马MECP2表达的时间和区域特异性破坏。我们发现MECP2是长期记忆形成所必需的，并且它控制了记忆合并所需的海马神经元的学习诱导的转录响应。此外，我们发现了在成年海马的MECP2功能，可能是认知完整性。我们展示MECP2在成年期内维持开发成熟的CA1神经元的染色质构造和表观遗传景观，并调节成人海马中神经元和免疫相关基因的表达。总体而言，我们的研究结果将MECP2鉴定为成年海马的维持因子，这些维持因子保留了基因组的信号响应性，并允许完整的认知功能。本研究提供了新的洞察MECP2如何维持成人脑功能，而且还进入了在RTT患者中观察到的认知障碍的机制，并突出了DNA甲基化解释在成人认知过程中的描述作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号