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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Autopsy‐proven case of paraneoplastic lower motor neuron disease with sensorimotor neuropathy due to Waldenstr?m's macroglobulinemia
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Autopsy‐proven case of paraneoplastic lower motor neuron disease with sensorimotor neuropathy due to Waldenstr?m's macroglobulinemia

机译：由于Waldentrom的宏观球蛋白血症，Sensicopotor神经病变的尸检的剖腹产神经病病例

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摘要

We report a case of a male patient with a 19‐year history of monoclonal and later polyclonal gammopathy who subsequently developed tetraparesis, bulbar palsy, and respiratory failure. Autopsy findings showed degeneration of the hypoglossal nuclei, prominent neuronal loss and atrophy in the anterior horn of the whole spinal cord despite the presence of mild astrocytosis, degeneration of the gracilis on one side, and infiltration of inflammatory cells, which included B cells and plasma cells in the anterior and posterior roots of the lumbar spinal cord, iliopsoas muscle, and perivascular area of the cervical cord. On immunostaining, cytoplasmic inclusions of phosphorylated transactivation response DNA‐binding protein of 43?kDa were observed in the motor neurons and astrocytes of the hypoglossal nuclei and whole spinal cord. The final diagnosis was paraneoplastic lower motor neuron disease with sensorimotor neuropathy due to Waldenstr?m's macroglobulinemia.
机译：我们举报了一个男性患者，具有19年的单克隆和后期多克隆血管病变的历史，随后发生了Tetrapasis，Bulbar Palsy和呼吸衰竭。 尽管存在轻度星形细胞胶质菌，但在一侧存在轻微星形症，并且炎症细胞的浸润，但尸检细胞膜的结果表明，尽管存在轻微的星形肌病，但是炎症细胞的浸润，炎症细胞的渗透，炎症细胞核核，突出的神经元损失和萎缩。 腰椎脊髓前后根，髂骨肌肉和颈髓的羽毛状面积细胞。 在免疫染色的情况下，在高核细胞核和全脊髓的电机神经元和星形胶质细胞中观察到43μSKDA的磷酸化转移反应DNA结合蛋白的细胞质夹杂物。 由于Waldenstr？M的宏观球蛋白血症，最终诊断是伴随着感觉运动神经病变的平原下电动神经病变。

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