Parvalbumin-Interneuron Output Synapses Show Spike-Timing-Dependent Plasticity that Contributes to Auditory Map Remodeling

Evan D. Vickers; Christopher Clark; Denys Osypenko; Alex Fratzl; Olexiy Kochubey; Bernhard Bettler; Ralf Schneggenburger

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Parvalbumin-Interneuron Output Synapses Show Spike-Timing-Dependent Plasticity that Contributes to Auditory Map Remodeling

机译：Parvalbumin-Interneuron输出突触显示有助于听觉地图重塑的峰值定时依赖性可塑性

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Parvalbumin (PV)-expressing interneurons mediate fast inhibition of principal neurons in many brain areas; however, long-term plasticity at PV-interneuron output synapses has been less well studied. In the auditory cortex, thalamic inputs drive reliably timed action potentials (APs) in principal neurons and PV-interneurons. Using paired recordings in the input layer of the mouse auditory cortex, we found a marked spike-timing-dependent plasticity (STDP) at PV-interneuron output synapses. Long-term potentiation of inhibition (iLTP) is observed upon postsynaptic (principal neuron) then presynaptic (PV-interneuron) AP firing. The opposite AP order causes GABAB-mediated long-term depression of inhibition (iLTD), which is developmentally converted to iLTP in an experience-dependent manner. Genetic deletion of GABABreceptors in principal neurons suppressed iLTD and produced deficits in auditory map remodeling. Output synapses of PV-interneurons thus show marked STDP, and one limb of this plasticity, GABAB-dependent iLTD, is a candidate mechanism for disinhibition during auditory critical period plasticity.

机译：Parvalbumin（PV）-Expring Interneurons在许多脑区中介绍了主要神经元的快速抑制;然而，PV-Interneuron输出突触的长期可塑性已经不太良好地研究。在听觉皮质中，丘脑输入在主要神经元和PV型中达到可靠定时的动作电位（APS）。在鼠标听觉皮质的输入层中使用配对录制，我们发现了PV-Interneuron输出突触的标记的峰值定时依赖性可塑性（STDP）。在突触后（主要神经元）上观察到抑制的长期增强（ILLTP），然后在突触前（PV-Interneuron）AP烧制。相对的AP顺序导致加法布介导的抑制（ILTD）的长期抑制，其以经验依赖性的方式显影转化为ILTP。主要神经元中的Gababrecoper的遗传缺失抑制了ILTD并产生了听觉地图重塑中的缺陷。因此，PV-Interneurons的输出突触显示标记为STDP，并且这种可塑性的一个肢体，Gabab依赖性ILTD是在听觉关键时期可塑性期间解读的候选机构。

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来源
《Neuron》 |2018年第4期|共22页
作者
Evan D. Vickers; Christopher Clark; Denys Osypenko; Alex Fratzl; Olexiy Kochubey; Bernhard Bettler; Ralf Schneggenburger;
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作者单位

Laboratory of Synaptic Mechanisms Brain Mind Institute School of Life Science école;

Laboratory of Synaptic Mechanisms Brain Mind Institute School of Life Science école;

Laboratory of Synaptic Mechanisms Brain Mind Institute School of Life Science école;

Laboratory of Synaptic Mechanisms Brain Mind Institute School of Life Science école;

Laboratory of Synaptic Mechanisms Brain Mind Institute School of Life Science école;

Department of Biomedicine Institute of Physiology University of Basel;

Laboratory of Synaptic Mechanisms Brain Mind Institute School of Life Science école;

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原文格式 PDF
正文语种 eng
中图分类神经病学;
关键词
synaptic inhibition; auditory cortex; critical period plasticity; fast-spiking interneurons; BDNF-TrkB signaling; GABABreceptor;

机译：突触抑制;听觉皮层;关键时期可塑性;快速尖锐的互核;BDNF-TRKB信号传导;Gababreceptor;

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1. Parvalbumin-Interneuron Output Synapses Show Spike-Timing-Dependent Plasticity that Contributes to Auditory Map Remodeling [J] . Evan D. Vickers, Christopher Clark, Denys Osypenko, Neuron . 2018,第4期

机译：Parvalbumin-Interneuron输出突触显示有助于听觉地图重塑的峰值定时依赖性可塑性
2. The tetrapartite synapse: Extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction [J] . Smith Alexander C. W., Scofield Michael D., Kalivas Peter W. Brain research . 2015,第Pta1期

机译：四方突触：细胞外基质重塑有助于皮质成瘾药物潜在的成瘾性
3. The tetrapartite synapse: Extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction [J] . Smith Alexander C. W., Scofield Michael D., Kalivas Peter W. Brain research . 2015,第Pta1期

机译：四方突触：细胞外基质重塑有助于皮质成瘾药物潜在的成瘾性
4. A bi-memristor synapse with spike-timing-dependent plasticity for on-chip learning in memristive neuromorphic systems [C] . Sagarvarma Sayyaparaju, Sherif Amer, Garrett S. Rose International Symposium on Quality Electronic Design . 2018

机译：双忆阻突触，具有依赖于尖峰时序的可塑性，可用于忆阻性神经形态系统的片上学习
5. The Integration of Multiple Sources of Sonic Hedgehog in the Spinal Cord Contribute to the Production of First-Born Oligodendrocyte Precursor Cells Which Become Critical For Synapse Remodeling in Response to Adult Motor Neuron Injury [D] . Starikov, Lev. 2019

机译：脊髓中的脊髓刺猬的多种来源的整合有助于生产第一出生的寡核细胞前体细胞，这对于成年运动神经元损伤响应于突触重塑而变得至关重要
6. The tetrapartite synapse: extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction [O] . Alexander C.W. Smith, Michael D. Scofield, Peter W. Kalivas -1

机译：四方突触：细胞外基质重塑有助于潜在的成瘾性皮质激素可塑性。
7. The tetrapartite synapse: Extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction [O] . Alexander C.W. Smith, Michael D. Scofield, Peter W. Kalivas 2015

机译：Tetrapartite Synapse：细胞外基质重塑有助于皮质切割塑性潜在的药物成瘾

Parvalbumin-Interneuron Output Synapses Show Spike-Timing-Dependent Plasticity that Contributes to Auditory Map Remodeling

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