Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain

Chen Gang; Zhang Yu-Qiu; Qadri Yawar J.; Serhan Charles N.; Ji Ru-Rong

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Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain

机译：痛苦中的小胶质细胞：病理发生和疼痛分辨的有害和保护作用

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The previous decade has seen a rapid increase in microglial studies on pain, with a unique focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous signaling molecules are altered in microglia and contribute to the pathogenesis of pain. Here, we discuss how microglial signaling regulates spinal cord synaptic plasticity in acute and chronic pain conditions with different degrees and variations of microgliosis. We highlight that microglial mediators such as pro- and anti-inflammatory cytokines are powerful neuromodulators that regulate synaptic transmission and pain via neuron-glial interactions. We also reveal an emerging role of microglia in the resolution of pain, in part via specialized pro-resolving mediators including resolvins, protectins, and maresins. We also discuss a possible role of microglia in chronic itch.

机译：前十年的疼痛微胶质研究迅速增加，在神经损伤和神经病疼痛后脊髓中的微细增值是独特的。在微胶质细胞中改变了许多信号分子，有助于疼痛的发病机制。在这里，我们讨论了微胶质信号如何调节急性和慢性疼痛条件下的脊髓突触塑性，不同程度和微细胞源源的变化。我们强调，微胶质介质，例如抗炎细胞因子等强大的神经调节剂，可通过神经元 - 胶质相互作用调节突触传播和疼痛。我们还通过专门的Pro-Solatmence调解器揭示了MICRIGLIA在疼痛中的出现作用，包括包括替换，保护蛋白和Maresins。我们还讨论了微胶质细胞在慢性瘙痒中的可能作用。

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《Neuron》 |2018年第6期|共20页
作者
Chen Gang; Zhang Yu-Qiu; Qadri Yawar J.; Serhan Charles N.; Ji Ru-Rong;
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作者单位

Nantong Univ Coinnovat Ctr Neuroregenerat Key Lab Neuroregenerat Jiangsu Nantong 226001 Jiangsu;

Fudan Univ Collaborat Innovat Ctr Brain Sci Inst Brain Sci Inst Neurobiol Shanghai 200032;

Duke Univ Med Ctr Dept Anesthesiol Ctr Translat Pain Med Durham NC 27710 USA;

Brigham &

Womens Hosp Dept Anesthesiol Perioperat &

Pain Med Hale Transformat Med Ctr Expt;

Duke Univ Med Ctr Dept Anesthesiol Ctr Translat Pain Med Durham NC 27710 USA;

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正文语种 eng
中图分类神经病学;
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1. Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain [J] . Chen Gang, Zhang Yu-Qiu, Qadri Yawar J., Neuron . 2018,第6期

机译：痛苦中的小胶质细胞：病理发生和疼痛分辨的有害和保护作用
2. Protective and detrimental roles of IL-10 in HIV pathogenesis [J] . KwonD.S., KaufmannD.E. European cytokine network . 2010,第3期

机译：IL-10在HIV发病机理中的保护作用和有害作用
3. Purinergic signaling in microglia in the pathogenesis of neuropathic pain [J] . Kazuhide INOUE Proceedings of the Japan Academy, Series B. Physical and Biological Sciences . 2017,第4期

机译：小胶质细胞中嘌呤能信号传导在神经性疼痛发病机理中的作用
4. ATP receptors of microglia involved in pain [C] . Kazuhide Inou Symposium on Purinergic Signalling in Neuron-Glia Interactions . 2006

机译：Microglia的ATP受体参与疼痛
5. Parental Responses to Children's Chronic Pain: A Developmental Perspective on Parental Protectiveness, Minimization and Monitoring of Pain. [D] . El-Behadli Gonzalez, Ana F. 2015

机译：父母对儿童慢性疼痛的反应：关于父母保护，最小化和监测疼痛的发展观点。
6. Purinergic signaling in microglia in the pathogenesis of neuropathic pain [O] . Kazuhide INOUE 2017

机译：小胶质细胞中嘌呤能信号传导在神经性疼痛发病机理中的作用
7. Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain [O] . Gang Chen, Yu-Qiu Zhang, Yawar J. Qadri, 2018

机译：痛苦中的小胶质细胞：病理发生和疼痛分辨的有害和保护作用

Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain

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