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首页> 外文期刊>Neuron >Coordinated Reductions in Excitatory Input to theNucleus AccumbensUnderlie Food Consumption
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Coordinated Reductions in Excitatory Input to theNucleus AccumbensUnderlie Food Consumption

机译:协调减少兴奋输入到核心核叛病症的食物消费

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摘要

Reward-seeking behavior is regulated by a diverse collection of inputs to the nucleus accumbens (NAc). The information encoded in each excitatory afferent to the NAc is unknown, in part because it is unclear when these pathways are active in relation to behavior. Here we compare the activity profiles of amygdala, hippocampal, and thalamic inputs to the NAc shell in mice performing a cued reward-seeking task using GCaMP-based fiber photometry. We find that the rostral and caudal ends of the NAc shell are innervated by distinct but intermingled populations of forebrain neurons that exhibit divergent feeding-related activity. In the rostral NAc shell, a coordinated network-wide reduction in excitatory drive correlates with feeding, and reduced input from individual pathways is sufficient to promote it. Overall, the data suggest that pathway-specific input activity at a population level may vary more across the NAc than between pathways.
机译:奖励行为是由对核心腺(NAC)的各种输入集合调节。 在NAC的每个兴奋剂中编码的信息部分是未知的,部分原因是当这些途径与行为有关时不清楚。 在这里,我们将Amygdala,海马和丘脑的活动谱与使用基于GCAMP的光纤测光测量的小鼠执行CUED奖励任务的小鼠中的NAC壳。 我们发现NAC壳的鼻腔和尾端通过截然不同但嵌入的前脑神经元的群体,其表现出发散的喂养相关的活性。 在rostral NaC壳中,兴奋驱动器的协调网络宽减少与饲养相关,并且从个体途径的减少输入足以促进它。 总体而言,数据表明,人口水平的途径特异性输入活度可能在NAC中比途径之间变得更大。

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