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Widespread and Highly Correlated Somato-dendritic Activity in Cortical Layer 5 Neurons

机译：皮质层5神经元在皮质层中的索曲霉活性高度相关

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Dendritic integration can expand the information-processing capabilities of neurons. However, the recruitment of active dendritic processing in vivo and its relationship to somatic activity remain poorly understood. Here, we use two-photon GCaMP6f imaging to simultaneously monitor dendritic and somatic compartments in the awake primary visual cortex. Activity in layer 5 pyramidal neuron somata and distal apical trunk dendrites shows surprisingly high functional correlation. This strong coupling persists across neural activity levels and is unchanged by visual stimuli and locomotion. Ex vivo combined somato-dendritic patch-clamp and GCaMP6f recordings indicate that dendritic signals specifically reflect local electrogenesis triggered by dendritic inputs or high-frequency bursts of somatic action potentials. In contrast to the view that dendrites are only sparsely recruited under highly specific conditions in vivo, our results provide evidence that active dendritic integration is a widespread and intrinsic feature of cortical computation.
机译：树突整合可以扩大神经元的信息处理能力。然而，招募体内活性树突状处理及其与躯体活动的关系仍然明白。在这里，我们使用双光子GCAMP6F成像同时监测唤醒原发性视觉皮层中的树突和体细胞室。第5层的活性金字塔神经元躯体和远端顶端枝形树枝状齿轮突显令人惊讶地具有令人惊讶的高功能相关性。这种强烈的耦合涵跨神经活动水平，并且通过视觉刺激和运动不变。 exvivo组合的索赔 - 树突贴片钳和Gcamp6f记录表明树突信号特异性地反映由树突式输入或体细胞作用电位的高频爆发引发的局部电突发。相反，由于树枝状物仅在体内高度特定条件下稀疏地招募，我们的结果提供了有效的树突整合是皮质计算的广泛和内在特征。

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