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Differential Recruitment of Competing Valence-Related Amygdala Networks during Anxiety

机译：焦虑期间竞争价值相关的Amygdala网络的差异招募

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摘要

The basolateral amygdala (BL) is involved in fear and anxiety, but it is currently unclear how the same network supports these two states. To address this question, we trained rats on appetitive and aversive conditioning in different contexts. Distinct groups of BL neurons displayed increased activity during appetitive (CS-R) versus aversive (CS-S) conditioned stimuli (R cells and S cells, respectively), and they were typically inhibited by the other CS. When the CS-S was presented in the safe context, rats entered a long-lasting, anxiety-like state characterized by increased inter-CS freezing and impaired reward seeking. During this state, a subset of BL cells ("state cells'') showed sustained shifts in baseline activity whose time course matched that of the behavioral changes. Many state cells with increased firing rates were S cells, whereas R cells only included state cells with reduced firing rates. Thus, anxiety involves persistent activity changes that are differentially expressed by subsets of valence-specific BL neurons.
机译：Basolateral Amygdala（BL）涉及恐惧和焦虑，但目前不清楚同一个网络如何支持这两个州。为了解决这个问题，我们在不同的背景下培训了大鼠的比例和厌恶调理。不同的BL神经元组在食欲（CS-R）与厌恶（CS-S）条件刺激（R细胞和S细胞）中显示出增加的活性，并且通常由其他Cs抑制。当CS-S在安全的背景下呈现时，大鼠进入了一种持久的焦虑状状态，其特征在于，CS间冻结和奖励追求受损。在此状态期间，BL细胞的子集（“状态小区”）在基线活动中显示了持续变化，其时间过程与行为变化的时间匹配。具有增加的烧制率的状态细胞是S细胞，而R细胞仅包括状态小区降低烧制率。因此，焦虑涉及持续的活性变化，其由价特异性BL神经元的子集差异表达。

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  • 来源
    《Neuron》 |2017年第1期|共13页
  • 作者

    Lee Seung-Chan; Amir Alon; Haufler Darrell; Pare Denis;

  • 作者单位

    Rutgers Univ Newark Ctr Mol &

    Behav Neurosci 197 Univ Ave Newark NJ 07102 USA;

    Rutgers Univ Newark Ctr Mol &

    Behav Neurosci 197 Univ Ave Newark NJ 07102 USA;

    Rutgers Univ Newark Ctr Mol &

    Behav Neurosci 197 Univ Ave Newark NJ 07102 USA;

    Rutgers Univ Newark Ctr Mol &

    Behav Neurosci 197 Univ Ave Newark NJ 07102 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
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