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Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters

机译：慢的AMPAR突触传递由Stargazin和谷氨酸转运蛋白确定

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摘要

AMPARs mediate the briefest synaptic currents in the brain by virtue of their rapid gating kinetics. However, at the mossy fiber-to-unipolar brush cell synapse in the cerebellum, AMPAR-mediated EPSCs last for hundreds of milliseconds, and it has been proposed that this time course reflects slow diffusion from a complex synaptic space. We show that upon release of glutamate, synaptic AMPARs were desensitized by transmitter by >90%. As glutamate levels subsequently fell, recovery of transmission occurred due to the presence of the AMPAR accessory protein stargazin that enhances the AMPAR response to low levels of transmitter. This gradual increase in receptor activity following desensitization accounted for the majority of synaptic transmission at this synapse. Moreover, the amplitude, duration, and shape of the synaptic response was tightly controlled by plasma membrane glutamate transporters, indicating that clearance of synaptic glutamate during the slow EPSC is dictated by an uptake process.
机译：通过快速的门控动力学，Ampars在大脑中调解最简短的突触电流。然而，在小脑中的苔藓纤维到单极刷细胞突起，Ampar介导的EPSC持续数百毫秒，并且已经提出了该时间过程从复杂的突触空间中反映了缓慢的扩散。我们表明，在谷氨酸释放后，通过> 90％的发射器脱敏的突触Ampars。随着谷氨酸水平随后下降，由于存在AMPAR辅助蛋白颗粒蛋白的存在，恢复透射的恢复，这提高了对低水平发射器的AMPAR反应。在脱敏后受体活性的这种逐渐增加占该突触的大多数突触传输。此外，突触响应的振幅，持续时间和形状被血浆膜谷氨酸转运蛋白紧密控制，表明在缓慢EPSC期间突触谷氨酸的间隙由摄取过程决定。

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  • 来源
    《Neuron》 |2017年第1期|共12页
  • 作者

    Lu Hsin-Wei; Balmer Timothy S.; Romero Gabriel E.; Trussell Laurence O.;

  • 作者单位

    Oregon Hlth &

    Sci Univ Neurosci Grad Program Portland OR 97201 USA;

    Oregon Hlth &

    Sci Univ Oregon Hearing Res Ctr Portland OR 97201 USA;

    Oregon Hlth &

    Sci Univ Dept Physiol &

    Pharmacol Portland OR 97201 USA;

    Oregon Hlth &

    Sci Univ Oregon Hearing Res Ctr Portland OR 97201 USA;

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  • 正文语种 eng
  • 中图分类 神经病学;
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