TREM2 and Amyloid Beta: A Love-Hate Relationship

Udeochu Joe; Sayed Faten A.; Gan Li

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TREM2 and Amyloid Beta: A Love-Hate Relationship

机译：Trem2和淀粉样蛋白β：爱恨的关系

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Mutations in TREM2 increase risk for late-onset AD. In this issue of Neuron, Zhao et al. (2018) show that TREM2 binds Ab to enhance its clearance and Lee et al. (2018) demonstrate that human TREM2 expression in AD mice ameliorates Ab-associated deficits.

机译：Trem2中的突变增加了后期广告的风险。在这个神经元问题中，赵等人。（2018）显示Trem2绑定AB以增强其清除和lee等。（2018）证明AD小鼠中的人体Trem2表达改善了AB相关的赤字。

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《Neuron》 |2018年第5期|共3页
作者
Udeochu Joe; Sayed Faten A.; Gan Li;
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Univ Calif San Francisco Gladstone Inst Neurol Dis San Francisco CA 94143 USA;

Univ Calif San Francisco Gladstone Inst Neurol Dis San Francisco CA 94143 USA;

Univ Calif San Francisco Gladstone Inst Neurol Dis San Francisco CA 94143 USA;

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正文语种 eng
中图分类神经病学;
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1. TREM2 and Amyloid Beta: A Love-Hate Relationship [J] . Udeochu Joe, Sayed Faten A., Gan Li Neuron . 2018,第5期

机译：Trem2和淀粉样蛋白β：爱恨的关系
2. Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the A beta 42:A beta 40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model [J] . Meilandt William J., Ngu Hai, Gogineni Alvin, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2020,第9期

机译：TREM2缺失减少了晚期淀粉样蛋白斑块积累，升高了β22：β40比率，加剧了PS2App Alzheimer小鼠模型中的轴突营养不良和树突脊柱损失
3. Relationships between expression of apolipoprotein E and beta-amyloid precursor protein are altered in proximity to Alzheimer beta-amyloid plaques: potential explanations from cell culture studies. [J] . Barger SW, DeWall KM, Liu L, Journal of Neuropathology and Experimental Neurology: Official Journal of the American Association of Neuropathologists, Inc . 2008,第8期

机译：载脂蛋白E与β-淀粉样蛋白前体蛋白表达之间的关系在阿尔茨海默氏症-β-淀粉样蛋白斑块附近发生改变：细胞培养研究的潜在解释。
4. Amyloid Beta42 Fibril Mimotope-Peptides Bind to Deposited Amyloid Beta in Brain Section of Alzheimer's Disease Model Mouse, J20 [C] . Koichi Tanaka, Makoto Yamaguchi, Masaaki Nishimura Japanese peptide symposium . 2010

机译：淀粉样蛋白β42纤维状模仿肽与阿尔茨海默病模型小鼠脑部中的沉积淀粉样蛋白β结合，J20
5. Role of amyloid precursor protein and amyloid-beta in Alzheimer's disease: Modulation of APP processing detection of Abeta oligomers, and their role in the pathogenesis and treatment of AD. [D] . Kim, Minkyu Leo. 2009

机译：淀粉样前体蛋白和淀粉样β在阿尔茨海默氏病中的作用：APP处理Abeta寡聚体检测的调节及其在AD的发病机理和治疗中的作用。
6. Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition [O] . Brittani R. Price, Tiffany L. Sudduth, Erica M. Weekman, 2020

机译：治疗性Trem2活化可改善淀粉样蛋白β沉积并改善淀粉样蛋白沉积5xFAD模型中的认知
7. Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition [O] . Brittani R. Price, Tiffany L. Sudduth, Erica M. Weekman, 2020

机译：治疗性Trem2活化可改善淀粉样蛋白β沉积并改善淀粉样蛋白沉积5xFAD模型中的认知

TREM2 and Amyloid Beta: A Love-Hate Relationship

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