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首页> 外文期刊>Neuron >Prefrontal-Periaqueductal Gray-Projecting Neurons Mediate Context Fear Discrimination
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Prefrontal-Periaqueductal Gray-Projecting Neurons Mediate Context Fear Discrimination

机译：前额外 - Periaqueyuctal灰色突出神经元调解背景恐惧歧视

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摘要

Survival critically depends on selecting appropriate defensive or exploratory behaviors and is strongly influenced by the surrounding environment. Contextual discrimination is a fundamental process that is thought to depend on the prefrontal cortex to integrate sensory information from the environment and regulate adaptive responses to threat during uncertainty. However, the precise prefrontal circuits necessary for discriminating a previously threatening context from a neutral context remain unknown. Using a combination of single-unit recordings and optogenetic manipulations, we identified a neuronal subpopulation in the dorsal medial prefrontal cortex (dmPFC) that projects to the lateral and ventrolateral periaqueductal gray (l/vlPAG) and is selectively activated during contextual fear discrimination. Moreover, optogenetic activation and inhibition of this neuronal population promoted contextual fear discrimination and generalization, respectively. Our results identify a subpopulation of dmPFC-l/vlPAG-projecting neurons that control switching between different emotional states during contextual discrimination.
机译：生存批判性地取决于选择适当的防御性或探索性行为，并受周围环境的强烈影响。上下文歧视是一种基本的过程，旨在依赖预先转移性皮质，以将来自环境的感官信息整合，并在不确定性期间调节对威胁的适应性反应。然而，用于区分从中立环境中涉及先前威胁的背景所需的精确前平面电路仍然未知。使用单单元录音和致敏操作的组合，我们鉴定了突出和口腔外侧Periaquenceal灰度（L / VLPAG）的背侧内侧前额叶皮质（DMPFC）中的神经元亚群，并在语境恐惧歧视期间选择性地激活。此外，显神经元群的致敏活化和抑制促进了上下文恐惧歧视和泛化。我们的结果确定了DMPFC-L / VLPAG突出的神经元的亚群，该诱导的神经元控制在上下文鉴别期间不同情绪状态之间的切换。

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  • 来源
    《Neuron》 |2018年第4期|共19页
  • 作者

    Rozeske Robert R.; Jercog Daniel; Karalis Nikolaos; Chaudun Fabrice; Khoder Suzana; Girard Delphine; Winke Nanci; Herry Cyril;

  • 作者单位

    INSERM Neuroctr Magendie U1215 146 Rue Leo Saignat F-33077 Bordeaux France;

    INSERM Neuroctr Magendie U1215 146 Rue Leo Saignat F-33077 Bordeaux France;

    INSERM Neuroctr Magendie U1215 146 Rue Leo Saignat F-33077 Bordeaux France;

    INSERM Neuroctr Magendie U1215 146 Rue Leo Saignat F-33077 Bordeaux France;

    INSERM Neuroctr Magendie U1215 146 Rue Leo Saignat F-33077 Bordeaux France;

    INSERM Neuroctr Magendie U1215 146 Rue Leo Saignat F-33077 Bordeaux France;

    INSERM Neuroctr Magendie U1215 146 Rue Leo Saignat F-33077 Bordeaux France;

    INSERM Neuroctr Magendie U1215 146 Rue Leo Saignat F-33077 Bordeaux France;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
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