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首页> 外文期刊>Neuron >Active Sampling State Dynamically Enhances Olfactory Bulb Odor Representation
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Active Sampling State Dynamically Enhances Olfactory Bulb Odor Representation

机译:主动采样状态动态增强嗅灯泡气味表示

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摘要

The olfactory bulb (OB) is the first site of synaptic odor information processing, yet a wealth of contextual and learned information has been described in its activity. To investigate the mechanistic basis of contextual modulation, we use whole-cell recordings tomeasure odor responses across rapid learning episodes in identified mitral/ tufted cells (MTCs). Across these learning episodes, diverse response changes occur already during the first sniff cycle. Motivated mice develop active sniffing strategies across learning that robustly correspond to the odor response changes, resulting in enhanced odor representation. Evoking fast sniffing in different behavioral states demonstrates that response changes during active sampling exceed those predicted from feedforward input alone. Finally, response changes are highly correlatedin tuftedcells, butnot mitral cells, indicating there are cell-type-specific effects on odor representation during active sampling. Altogether, we show that active sampling is strongly associated with enhanced OB responsiveness on rapid timescales.
机译:嗅球灯泡(OB)是突触气味信息处理的第一个站点,但在其活动中已经描述了丰富的上下文和学习信息。为了调查语境调制的机制基础,我们在鉴定的二尖瓣/簇绒细胞(MTCS)中的快速学习发作中使用全部细胞录音。在这些学习剧集中,在第一嗅循环期间已经发生了不同的反应变化。有动机的小鼠在学习方面发挥积极的嗅探策略,鲁棒地对应于气味反应变化,导致气味表示增强。在不同行为状态下唤起快速嗅探展示了主动采样期间的响应变化超过了单独从前馈输入预测的那些。最后,响应变化是高度相关的簇绒细胞,絮凝二尖瓣细胞,表明在主动采样期间有对气味表示的细胞类型特异性效果。完全,我们表明主动采样与快速时间尺度增强的ob响应性强烈相关。

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  • 来源
    《Neuron》 |2018年第6期|共20页
  • 作者单位

    Francis Crick Inst Neurophysiol Behav Lab London NW1 5AT England;

    Francis Crick Inst Neurophysiol Behav Lab London NW1 5AT England;

    Francis Crick Inst Neurophysiol Behav Lab London NW1 5AT England;

    Francis Crick Inst Neurophysiol Behav Lab London NW1 5AT England;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
  • 关键词

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