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首页> 外文期刊>Neuron >Ultrasonic Neuromodulation Causes Widespread Cortical Activation via an Indirect Auditory Mechanism
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Ultrasonic Neuromodulation Causes Widespread Cortical Activation via an Indirect Auditory Mechanism

机译：超声波神经调节通过间接听觉机制导致广泛的皮质激活

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Ultrasound has received widespread attention as an?emerging technology for targeted, non-invasive neuromodulation based on its ability to evoke electrophysiological and motor responses in animals. However, little is known about the spatiotemporal pattern of ultrasound-induced brain activity that could drive these responses. Here, we address this question by combining focused ultrasound with wide-field optical imaging of calcium signals in transgenic mice. Surprisingly, we find cortical activity patterns consistent with indirect activation of auditory pathways rather than direct neuromodulation at the ultrasound focus. Ultrasound-induced activity is similar to that evoked by audible sound. Furthermore, both ultrasound and audible sound elicit motor responses consistent with a startle reflex, with both responses reduced by chemical deafening. These findings reveal an indirect auditory mechanism for ultrasound-induced cortical activity and movement requiring careful consideration in future development of ultrasonic neuromodulation as a tool in neuroscience research.
机译：超声波由于其在动物中唤起电生理和电动机反应的能力而受到普遍的关注然而，关于超声诱导的脑活动的时空模式知之甚少，可以推动这些反应。在这里，我们通过将聚焦超声与转基因小鼠中的钙信号的宽场光学成像组合来解决这个问题。令人惊讶的是，我们发现皮质活动模式与间接激活听觉途径，而不是在超声波焦点的直接神经调节。超声诱导的活动类似于可听声音引起的活动。此外，超声波和听觉的声音引发电动机响应与爆发反射一致，两个反应通过化学震耳降低。这些发现揭示了超声诱导的皮质活动和运动的间接听觉机制，需要仔细考虑的超声神经调节作为神经科学研究的工具。

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