Transforming the Choice Outcome to an Action Plan in Monkey Lateral Prefrontal Cortex: A Neural Circuit Model

Yim Man Yi; Cai Xinying; Wang Xiao-Jing

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Transforming the Choice Outcome to an Action Plan in Monkey Lateral Prefrontal Cortex: A Neural Circuit Model

机译：将选择结果转换为猴子横向前额叶皮质中的行动计划：神经电路模型

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In economic decisions, we make a good-based choice first, then we transform the outcome into an action to obtain the good. To elucidate the network mechanisms for such transformation, we constructed a neural circuit model consisting of modules representing choice, integration of choice with target locations, and the final action plan. We examined three scenarios regarding how the final action plan could emerge in the neural circuit and compared their implications with experimental data. Our model with heterogeneous connectivity predicts the coexistence of three types of neurons with distinct functions, confirmed by analyzing the neural activity in the lateral prefrontal cortex (LPFC) of behaving monkeys. We obtained a much more distinct classification of functional neuron types in the ventral than the dorsal region of LPFC, suggesting that the action plan is initially generated in ventral LPFC. Our model offers a biologically plausible neural circuit architecture that implements good-to-action transformation during economic choice.

机译：在经济决策中，我们首先做出一个良好的选择，然后将结果转变为获得良好的行动。为了阐明这种转换的网络机制，我们构建了一种神经电路模型，包括表示选择的模块，与目标位置的选择集成以及最终动作计划。我们检查了三种情景，了解最终行动计划如何在神经回路中出现，并将其与实验数据的影响进行了比较。我们具有异质连接的模型预测了三种类型的神经元的共存具有不同功能，通过分析表现猴子的横向前额叶皮质（LPFC）中的神经活性来证实。我们在腹侧的功能神经元类型中获得了比LPFC背部区域更明显的功能神经元类型的分类，这表明动作计划最初在腹侧LPFC中产生。我们的型号提供了一种生物合理的神经电路架构，可在经济选择期间实现良好的动作转变。

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《Neuron》 |2019年第3期|共18页
作者
Yim Man Yi; Cai Xinying; Wang Xiao-Jing;
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作者单位

New York Univ Shanghai Shanghai 200122 Peoples R China;

New York Univ Shanghai Shanghai 200122 Peoples R China;

East China Normal Univ Sch Psychol &

Cognit Sci Minist Educ Shanghai Key Lab Brain Funct Genom;

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正文语种 eng
中图分类神经病学;
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专利

1. Transforming the Choice Outcome to an Action Plan in Monkey Lateral Prefrontal Cortex: A Neural Circuit Model [J] . Yim Man Yi, Cai Xinying, Wang Xiao-Jing Neuron . 2019,第3期

机译：将选择结果转换为猴子横向前额叶皮质中的行动计划：神经电路模型
2. Early involvement of prefrontal cortex in bottom-up visual attention: comparison of neural response times in monkey prefrontal and posterior parietal cortex [J] . Fumi Katsuki, Christos Constantinidis Journal of vision . 2011,第11期

机译：前额叶皮层早期参与自下而上的视觉注意：猴子前额叶皮层和后顶叶皮层神经反应时间的比较
3. Neural Encoding of Self and Another Agent's Goal in the Primate Prefrontal Cortex: Human–Monkey Interactions [J] . RossellaFalcone, EmilianoBrunamonti, StefanoFerraina, Cerebral cortex . 2016,第12期

机译：神经编码自我和另一个代理人在灵长类动物前额外皮层中的目标：人猴相互作用
4. The structural basis of information transfer from medial temporal lobe to prefrontal cortex in the macaque monkey [C] . Ahmet Bozkurt, Lars Kamper, Klaas E. Stephan, Computational neuroscience meeting . 2002

机译：从内侧颞叶的信息转移到猕猴前额叶皮质的结构基础
5. Neural circuits linking the prefrontal cortex with the anterior medial and ventral anterior thalamic nuclei in the Rhesus monkey: Pathways underlying emotions, memory and executive control. [D] . Xiao, Danqing. 2003

机译：恒河猴中前额叶皮层与丘脑前内侧和腹侧前核之间的神经回路：情绪，记忆和执行控制的潜在途径。
6. Dynamic Axis-Tuned Cells in the Monkey Lateral Prefrontal Cortex during a Path-Planning Task [O] . Kazuhiro Sakamoto, Naohiro Saito, Shun Yoshida, 2020

机译：在路径规划任务期间猴子横向前额定皮层中的动态轴调谐单元
7. Dynamic Axis-Tuned Cells in the Monkey Lateral Prefrontal Cortex during a Path-Planning Task [O] . Kazuhiro Sakamoto, Naohiro Saito, Shun Yoshida, 2019

机译：在路径规划任务期间猴子横向前额定皮层中的动态轴调谐单元

Transforming the Choice Outcome to an Action Plan in Monkey Lateral Prefrontal Cortex: A Neural Circuit Model

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