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首页> 外文期刊>Neuron >A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain
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A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain

机译：特异性细胞特异性受体介导神经源性炎症和疼痛

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摘要

Mast cells can be found in close proximity to peripheral nerve endings where, upon activation, they release a broad range of pro-inflammatory cytokines and chemokines. However, the precise mechanism underlying this so-called neurogenic inflammation and associated pain has remained elusive. Here we report that the mast-cell-specific receptor Mrgprb2 mediates inflammatory mechanical and thermal hyperalgesia and is required for recruitment of innate immune cells at the injury site. We also found that the neuropeptide substance P (SP), an endogenous agonist of Mrgprb2, facilitates immune cells' migration via Mrgprb2. Furthermore, SP activation of the human mast cell led to the release of multiple pro-inflammatory cytokines and chemokines via the human homolog MRGPRX2. Surprisingly, the SP-mediated inflammatory responses were independent of its canonical receptor, neurokinin-1 receptor (NK-1R). These results identify Mrgprb2/X2 as an important neuroimmune modulator and a potential target for treating inflammatory pain.
机译：肥大细胞可以靠近周围神经末梢，在激活时，它们释放出广泛的促炎细胞因子和趋化因子。然而，这种所谓的神经发生炎症和相关疼痛的精确机制仍然难以捉摸。在这里，我们报告称，肥大细胞特异性受体MRGPRB2介导炎症机械和热痛觉体，并且需要在损伤部位募集生先生免疫细胞。我们还发现神经肽物质P（SP），MRGPRB2的内源性激动剂，促进免疫细胞通过MRGPRB2迁移。此外，人肥大细胞的SP激活导致通过人同源物MRGPRX2释放多种促炎细胞因子和趋化因子。令人惊讶的是，SP介导的炎症反应均独立于其典型受体，神经蛋白-1受体（NK-1R）。这些结果将MRGPRB2 / X2鉴定为重要的神经免疫调节剂和治疗炎症疼痛的潜在靶标。

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  • 来源
    《Neuron》 |2019年第3期|共12页
  • 作者

    Green Dustin P.; Limjunyawong Nathachit; Gour Naina; Pundir Priyanka; Dong Xinzhong;

  • 作者单位

    Johns Hopkins Univ Solomon H Snyder Dept Neurosci Ctr Sensory Biol Sch Med Baltimore MD 21218;

    Johns Hopkins Univ Solomon H Snyder Dept Neurosci Ctr Sensory Biol Sch Med Baltimore MD 21218;

    Johns Hopkins Univ Solomon H Snyder Dept Neurosci Ctr Sensory Biol Sch Med Baltimore MD 21218;

    Johns Hopkins Univ Solomon H Snyder Dept Neurosci Ctr Sensory Biol Sch Med Baltimore MD 21218;

    Johns Hopkins Univ Solomon H Snyder Dept Neurosci Ctr Sensory Biol Sch Med Baltimore MD 21218;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
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