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首页> 外文期刊>Neuron >Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity
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Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity

机译：核心诱发的核心诱发的突触调节需要星形胶质细胞活性

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摘要

Dopamine is involved in physiological processes like learning and memory, motor control and reward, and pathological conditions such as Parkinson's disease and addiction. In contrast to the extensive studies on neurons, astrocyte involvement in dopaminergic signaling remains largely unknown. Using transgenic mice, optogenetics, and pharmacogenetics, we studied the role of astrocytes on the dopaminergic system. We show that in freely behaving mice, astro-cytes in the nucleus accumbens (NAc), a key reward center in the brain, respond with Ca2+ elevations to synaptically released dopamine, a phenomenon enhanced by amphetamine. In brain slices, synaptically released dopamine increases astrocyte Ca2+, stimulates ATP/adenosine release, and depresses excitatory synaptic transmission through activation of presynaptic A(1) receptors. Amphetamine de-presses neurotransmission through stimulation of astrocytes and the consequent A(1) receptor activation. Furthermore, astrocytes modulate the acute behavioral psychomotor effects of amphetamine. Therefore, astrocytes mediate the dopamine- and amphetamine-induced synaptic regulation, revealing a novel cellular pathway in the brain reward system.
机译：多巴胺参与了学习和记忆，电机控制和奖励等生理过程，以及帕金森病和成瘾等病理条件。与对神经元的广泛研究相比，白细胞参与多巴胺能信号传导仍然很大程度上是未知的。使用转基因小鼠，邻接性和药物发生，我们研究了星形胶质细胞对多巴胺能系统的作用。我们表明，在自由表现下的小鼠中，核常规（NAC）中的Astro-Cytes，大脑中的一个关键奖励中心，用Ca2 +升级反应突触释放的多巴胺，Amphetamine增强的现象。在脑切片中，突触释放的多巴胺增加了星形胶质细胞Ca2 +，刺激ATP /腺苷释放，并通过激活突触前A（1）受体来抑制兴奋性突触传递。 Amphetamine通过刺激星形胶质细胞和随后的A（1）受体激活来压制神经递质。此外，星形胶质细胞调节急性行为的精神病患者对甜胺的影响。因此，星形胶质细胞介导多巴胺和安非他明诱导的突触调节，揭示了大脑奖励系统中的新细胞途径。

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