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首页> 外文期刊>Neuron >Paraventricular Thalamus Projection Neurons Integrate Cortical and Hypothalamic Signals for Cue-Reward Processing
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Paraventricular Thalamus Projection Neurons Integrate Cortical and Hypothalamic Signals for Cue-Reward Processing

机译：paraventricular丘脑投影神经元对提示加工的皮质和下丘脑信号集成了皮质和下丘脑信号

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The paraventricular thalamus (PVT) is an interface for brain reward circuits, with input signals arising from structures, such as prefrontal cortex and hypothalamus, that are broadcast to downstream limbic targets. However, the precise synaptic connectivity, activity, and function of PVT circuitry for reward processing are unclear. Here, using in vivo two-photon calcium imaging, we find that PVT neurons projecting to the nucleus accumbens (PVT-NAc) develop inhibitory responses to reward-predictive cues coding for both cue-reward associative information and behavior. The multiplexed activity in PVT-NAc neurons is directed by opposing activity patterns in prefrontal and lateral hypothalamic afferent axons. Further, we find that prefrontal cue encoding may maintain accurate cue-reward processing, as optogenetic disruption of this encoding induced long-lasting effects on downstream PVT-NAc cue responses and behavioral cue discrimination. Together, these data reveal that PVT-NAc neurons act as an interface for reward processing by integrating relevant inputs to accurately inform reward-seeking behavior.
机译：椎间盘丘脑（PVT）是用于脑奖励电路的界面，具有从结构，例如前额叶皮层和下丘脑的结构引起的输入信号，其被广播到下游肢体目标。然而，PVT电路用于奖励处理的精确突触连接，活动和功能尚不清楚。在这里，使用体内两光核钙成像，我们发现PVT神经元突出到核心（PVT-NAC）制定抑制响应，以奖励对CUE奖励联合信息和行为的奖励预测性提示。 PVT-NAC神经元中的多重活性通过前额叶和侧面下丘脑传入轴突中的相反活性模式引导。此外，我们发现前额提示编码可以维持准确的提示奖励处理，作为对该编码的光学破坏对下游PVT-NAC CUE响应和行为提示歧视的持久影响。这些数据一起显示PVT-NAC神经元作为奖励处理的接口，通过整合相关输入来准确地通知寻求奖励行为。

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