...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >Endocannabinoid Signaling Collapse Mediates Stress-Induced Amygdalo-Cortical Strengthening
【24h】

Endocannabinoid Signaling Collapse Mediates Stress-Induced Amygdalo-Cortical Strengthening

机译：Endocannabinoid信号传导塌陷介导应激诱导的杏仁型 - 皮质强化

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Functional coupling between the amygdala and the dorsomedial prefrontal cortex (dmPFC) has been implicated in the generation of negative affective states; however, the mechanisms by which stress increases amygdala-dmPFC synaptic strength and generates anxiety-like behaviors are not well understood. Here, we show that the mouse basolateral amygdala (BLA)-prelimbic prefrontal cortex (pIPFC) circuit is engaged by stress and activation of this pathway in anxiogenic. Furthermore, we demonstrate that acute stress exposure leads to a lasting increase in synaptic strength within a reciprocal BLA-pIPFC-BLA subcircuit. Importantly, we identify 2-arachidonoylglycerol (2-AG)-mediated endocannabinoid signaling as a key mechanism limiting glutamate release at BLA-pIPFC synapses and the functional collapse of multimodal 2-AG signaling as a molecular mechanism leading to persistent circuit-specific synaptic strengthening and anxiety-like behaviors after stress exposure. These data suggest that circuit-specific impairment in 2-AG signaling could facilitate functional coupling between the BLA and pIPFC and the translation of environmental stress to affective pathology.
机译：Amygdala和背体前额定皮层（DMPFC）之间的功能耦合已涉及产生负面情感状态的产生;然而，压力增加了asygdala-dmpfc突触强度并产生类似焦虑的行为的机制尚不清楚。在这里，我们表明小鼠基底间amygdala（BLA） - 预端前额定皮层皮质（PIPFC）电路由焦虑的应力和激活该途径的胁迫和激活。此外，我们证明急性压力暴露导致互易BLA-PIPFC-BLA轴内突触强度的持久增加。重要的是，我们鉴定2- arachidonallgycerol（2-Ag）介导的内胆蛋白信号传导作为限制BLA-PIPFC突起的谷氨酸释放的关键机制和多模式2-Ag信号传导的功能塌陷，作为导致持续电路特异性突触强化的分子机制压力暴露后的焦虑行为。这些数据表明，2-AG信令中的电路特定损伤可以促进BLA和PIPFC之间的功能耦合以及对情感病理的环境压力的翻译。

著录项

  • 来源
    《Neuron》 |2020年第6期|共21页
  • 作者

    Marcus David J.; Bedse Gaurav; Gaulden Andrew D.; Ryan James D.; Kondev Veronika; Winters Nathan D.; Rosas-Vidal Luis E.; Altemus Megan; Mackie Ken; Lee Francis S.; Delpire Eric; Patel Sachin;

  • 作者单位

    Vanderbilt Univ Med Ctr Dept Psychiat &

    Behav Sci Nashville TN 37232 USA;

    Vanderbilt Univ Med Ctr Dept Psychiat &

    Behav Sci Nashville TN 37232 USA;

    Vanderbilt Univ Med Ctr Dept Psychiat &

    Behav Sci Nashville TN 37232 USA;

    Weill Cornell Med Dept Psychiat New York NY 10065 USA;

    Vanderbilt Univ Med Ctr Dept Psychiat &

    Behav Sci Nashville TN 37232 USA;

    Vanderbilt Univ Med Ctr Dept Psychiat &

    Behav Sci Nashville TN 37232 USA;

    Vanderbilt Univ Med Ctr Dept Psychiat &

    Behav Sci Nashville TN 37232 USA;

    Vanderbilt Univ Med Ctr Dept Psychiat &

    Behav Sci Nashville TN 37232 USA;

    Indiana Univ Gill Ctr Biomol Sci Bloomington IN 47405 USA;

    Weill Cornell Med Dept Psychiat New York NY 10065 USA;

    Vanderbilt Univ Med Ctr Dept Anesthesiol Nashville TN 37232 USA;

    Vanderbilt Univ Med Ctr Dept Psychiat &

    Behav Sci Nashville TN 37232 USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号