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首页> 外文期刊>Neuropharmacology >Melanin concentrating hormone modulates oxytocin-mediated marble burying
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Melanin concentrating hormone modulates oxytocin-mediated marble burying

机译：黑色素浓缩激素调节催产素介导的大理石埋

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摘要

Abstract Repetitive and perseverative behaviors are common features of a number of neuropsychiatric diseases such as Angelman's syndrome, Tourette's syndrome, obsessive-compulsive disorder, and autism spectrum disorders. The oxytocin system has been linked to the regulation of repetitive behavior in both animal models and humans, but many of its downstream targets have still to be found. We report that the melanin-concentrating hormone (MCH) system is a target of the oxytocin system in regulating one repetitive behavior, marble burying. First we report that nearly 60% of MCH neurons express oxytocin receptors, and demonstrate using rabies mediated tract tracing that MCH neurons receive direct presynaptic input from oxytocin neurons. Then we show that MCH receptor knockout (MCHR1KO) mice and MCH ablated animals display increased marble burying response while central MCH infusion decreases it. Finally, we demonstrate the downstream role of the MCH system on oxytocin mediated marble burying by showing that central infusions of MCH and oxytocin alone or together reduce it while antagonizing the MCH system blocks oxytocin-mediated reduction of this behavior. Our findings reveal a novel role for the MCH system as a mediator of the role of oxytocin in regulating marble-burying behavior in mice. Highlights ? OT regulates marble-burying through the MCH system. ? Disrupting the MCH system increases marble-burying in mice.
机译：摘要重复和持续性行为是许多神经精神疾病的常见特征，如angelman综合征，Tourette综合征，强迫症和自闭症谱系障碍。催产素系统已经与动物模型和人类中的重复行为的调节有关，但仍有许多下游目标仍然存在。我们报道了黑色素浓缩激素（MCH）系统是调节一种重复行为，大理石埋设的催产素系统的靶标。首先，我们报告称，近60％的MCH神经元表达催产素受体，并使用狂犬病介导的道路追踪该MCH神经元从催产素神经元接受直接突触前输入。然后，我们表明MCH受体敲除（MCHR1KO）小鼠和MCH消融动物显示出增加的大理石掩埋反应，而中央MCH输注降低。最后，我们证明了MCH系统对催产素介导的大理石掩埋的下游作用，通过表明单独的MCH和催产素的中央输注或一起减少它，同时拮抗MCH系统阻断催眠素介导的这种行为的降低。我们的研究结果揭示了MCH系统作为催产素作用在调节小鼠中的大理石埋葬行为的介质的介质。强调 ？ OT调节通过MCH系统的大理石埋。还破坏MCH系统增加了大理石埋在小鼠中。

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