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Prevention and treatment of peritoneal dialysis membrane failure.

机译:预防和治疗腹膜透析膜衰竭。

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A review is given on the definition of peritoneal membrane failure, its pathogenesis, mechanisms of impaired ultrafiltration, and prevention and treatment of membrane failure. In the absence of clinical signs of peritoneal sclerosis and of nonresolving peritonitis, membrane failure is best defined as net ultrafiltration of less than 400 mL/4 hours on a 3.86% glucose-based dialysis solution. Evidence has been accumulating that glucose is a major pathogenetic factor. Reduced exposure to glucose is the most important preventive measurement. Strategies for treatment are discussed. The use of icodextrin-based dialysis solutions is an attractive possibility to reduce glucose exposure.
机译:综述了腹膜功能衰竭的定义,发病机理,超滤功能受损的机制以及膜功能衰竭的预防和治疗。在没有腹膜硬化和未解决的腹膜炎的临床体征的情况下,膜衰竭的最佳定义是在3.86%的基于葡萄糖的透析溶液上进行的净超滤少于400 mL / 4小时。越来越多的证据表明葡萄糖是主要的致病因素。减少接触葡萄糖是最重要的预防措施。讨论了治疗策略。基于艾考糊精的透析溶液的使用是减少葡萄糖暴露的有吸引力的可能性。

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