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首页> 外文期刊>Neuropsychology >Triglycerides Are Negatively Correlated With Cognitive Function in Nondemented Aging Adults
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Triglycerides Are Negatively Correlated With Cognitive Function in Nondemented Aging Adults

机译：甘油三酯与Nondeded成年人的认知功能呈负相关

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Objective: Vascular risk factors like hyperlipidemia may adversely affect brain function. We hypothesized that increased serum triglycerides are associated with decreased executive function and memory in nondemented elderly subjects. We also researched possible vascular mediators and white matter microstructure as assessed with diffusion tensor imaging (DTI). Design/Method: Participants were 251 nondemented elderly adults (54% male) with a mean age of 78 (SD = 6.4; range: 62-94) years and a mean education of 15.6 (SD = 2.9; range: 8-23) years. Fasting blood samples were used to detect serum triglyceride and low-density lipoprotein (LDL) levels along with ApoE4 status. DTI was used to determine whole brain fractional anisotropy (FA). Composite executive and memory scores were derived from item response theory. Clinical Dementia Rating (CDR) scores provided informant-based measures of daily functioning. Results: Triglyceride levels were inversely correlated with executive function, but there was no relationship with memory. Controlling for age, gender, and education did not affect this correlation. This relationship persisted after controlling for vascular risk factors like LDL, total cholesterol, CDR and ApoE4 status. Lastly, adding whole-brain FA to the model did not affect the correlation between triglycerides and executive function. Conclusion: Triglyceride levels are inversely correlated with executive function in nondemented elderly adults after controlling for age, education, gender, total cholesterol, LDL, ApoE4 status, CDR, and white-matter microstructure. The fact that the effect of triglycerides on cognition was not clearly mediated by vascular risks or cerebrovascular injury raises questions about widely held assumptions of how triglycerides might impact cognition function.
机译：目的：高脂血症等血管危险因素可能对大脑功能产生不利影响。我们假设增加的血清甘油三酯与新的老年人受试者的执行功能和记忆量下降有关。我们还研究了通过扩散张量成像（DTI）评估的可能的血管介质和白质微观结构。设计/方法：参与者是251名令人兴趣的老年人（54％男性），平均年龄为78（SD = 6.4;范围：62-94）年，平均教育为15.6（SD = 2.9;范围：8-23）年。使用空腹血液样品与APOE4状态一起检测血清甘油三酯和低密度脂蛋白（LDL）水平。 DTI用于确定全脑分数各向异性（FA）。综合执行和记忆分数来自项目响应理论。临床痴呆评级（CDR）得分提供了基于Informant的日常运作措施。结果：甘油三酯水平与行政功能相反，但与记忆没有关系。控制年龄，性别和教育并没有影响这种相关性。这种关系在控制LDL，总胆固醇，CDR和APOE4状态等血管危险因素后持续存在。最后，将全脑FA添加到模型不影响甘油三酯和执行功能之间的相关性。结论：在控制年龄，教育，性别，总胆固醇，LDL，APOE4状态，CDR和白品微观结构之后，甘油三酯水平与Nondeded老年人的行政功能与Nondeded老年人的行政功能相关联。甘油三酯对认知的影响没有明确通过血管风险或脑血管伤害介导的问题提出了关于甘油三酯如何影响认知功能的广泛存在假设的问题。

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