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首页> 外文期刊>Neuropsychology >Effect of Age and Level of Education on Neurocognitive Impairment in HIV Positive Zambian Adults
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Effect of Age and Level of Education on Neurocognitive Impairment in HIV Positive Zambian Adults

机译：年龄和教育水平对艾滋病毒阳性赞比亚成年人神经认知障碍的影响

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Objective: Older age and lower education levels are known to be associated with worse neurocognitive (NC) performance in healthy adults, and individuals with HIV infection may experience accelerated brain/cognition aging. However, higher education may possibly protect against HIV-associated neurocognitive disorders (HAND). The aim of the current cross-sectional study was to assess the effect of age and education in an HIV-1 clade C infected adult population in urban Zambia. Method: Demographically corrected Zambian norms on a neuropsychological (NP) test battery were used to correct for normal age and education effects. The study assessed 286 HIV positive (+) males (37.1%) and females (62.9%) with a mean age of 41.35 (SD = 8.56) and mean years of education = 10.16 (SD = 2.18). A comprehensive NP test battery was used to assess cognitive domains frequently affected by HIV: attention/working memory, learning/and delayed recall, executive function, verbal fluency, processing speed, verbal and visual episodic memory, and fine motor skills. Results: In younger HIV + Zambians, higher education evidenced protective effects against NC impairments overall, and for the specific domains of executive functions, learning and speed of information processing. Impairment scores did not support accelerated overall brain aging although the restricted age range and relative youth of our total sample may have precluded detection of such tendencies. Conclusions: The present study raises the need to investigate factors that could be implicated in the poor neurocognitive performance among the younger, less educated HIV + individuals in Zambia.
机译：目的：已知老年人和较低的教育水平与健康成年人的较差的神经认知（NC）表现相关，艾滋病毒感染的个体可能会经历加速的脑/认知老化。然而，高等教育可能可以防止艾滋病毒相关的神经认知障碍（手）。目前的横截面研究的目的是评估在城市赞比亚城市赞比亚HIV-1 C感染的成年人口中的年龄和教育的影响。方法：在神经心理学（NP）测试电池上的人口统计学校正规范用于纠正正常年龄和教育效果。该研究评估了286名HIV阳性（+）雄性（37.1％）和女性（62.9％），平均年龄为41.35（SD = 8.56），平均教育年龄= 10.16（SD = 2.18）。综合NP测试电池用于评估经常受艾滋病毒影响的认知结构域：注意/工作记忆，学习/和延迟召回，执行功能，口头流畅性，加工速度，口头和视觉情节内存，以及精细的运动技能。结果：艾滋病毒+赞比亚人，高等教育总体上证明了对NC障碍的保护作用，以及执行职能，学习和信息处理速度的特定领域。减值分数不支持加速整体脑老龄化，尽管我们的总样本的禁区年龄范围和相对青少年可能会妨碍检测此类趋势。结论：本研究提出了需要探讨可能涉及在赞比亚的年轻，受过教育的艾滋病毒+个体的贫困神经认知性能不良的因素的因素。

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