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首页> 外文期刊>Materials science & engineering, C. Materials for Biogical applications >Recent advances in microneedle composites for biomedical applications: Advanced drug delivery technologies
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Recent advances in microneedle composites for biomedical applications: Advanced drug delivery technologies

机译：MicroEdle复合材料的最新进展，用于生物医学应用：高级药物交付技术

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In the twenty-first century, microneedles based drug delivery is drawing attention worldwide in the research due to current signs of progress in the controlled release drug delivery through microneedles. The microneedles represent a promising technology to deliver therapeutic compounds into the skin for chronic complications like osteoporosis, diabetes, cancer and induction of immune responses from protein and DNA vaccines. However, the delivery of hydrophilic drugs and macromolecular agents are challenging. In this write up authors included the meticulous illustration of the chronological development of fabrication of microneedles with respect to an assortment of techniques, their modifications, clinical trials and regulatory perspectives period of 2000-2019. This review summarizes characterization, fabrications, biological applications and challenges. Additionally, relevant patents based on microneedle from USPTO) database are also highlighted.
机译：在二十一世纪，基于微针的药物交付是在全球上引起关注，因为目前通过微针的控制释放药物递送的目前的进展迹象。 微针代表了有希望的技术，可将治疗化合物递送到皮肤上，以进行骨质疏松症，糖尿病，癌症等免疫反应等慢性并发症。 然而，亲水性药物和大分子剂的递送是挑战性的。 在这篇写作中，作者包括关于各种技术的微针的制造时间表的细致例证，其修改，临床试验和2000-2019期的调节期。 本综述总结了表征，制造，生物学应用和挑战。 此外，还突出显示了基于USPTO的微针的相关专利。

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