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首页> 外文期刊>Neuroinformatics >A Comparison of Accelerated and Non-accelerated MRI Scans for Brain Volume and Boundary Shift Integral Measures of Volume Change: Evidence from the ADNI Dataset
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A Comparison of Accelerated and Non-accelerated MRI Scans for Brain Volume and Boundary Shift Integral Measures of Volume Change: Evidence from the ADNI Dataset

机译：大脑体积和边界换层积分措施的加速和非加速MRI扫描的比较：来自Adni DataSet的证据

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The aim of this study was to assess whether the use of accelerated MRI scans in place of non-accelerated scans influenced brain volume and atrophy rate measures in controls and subjects with mild cognitive impairment and Alzheimer's disease. We used data from 861 subjects at baseline, 573 subjects at 6 months and 384 subjects at 12 months from the Alzheimer's Disease Neuroimaging Initiative (ADNI). We calculated whole-brain, ventricular and hippocampal atrophy rates using the k-means boundary shift integral (BSI). Scan quality was visually assessed and the proportion of good quality accelerated and non-accelerated scans compared. We also compared MMSE scores, vascular burden and age between subjects with poor quality scans with those with good quality scans. Finally, we estimated sample size requirements for a hypothetical clinical trial when using atrophy rates from accelerated scans and non-accelerated scans. No significant differences in whole-brain, ventricular and hippocampal volumes and atrophy rates were found between accelerated and non-accelerated scans. Twice as many non-accelerated scan pairs suffered from at least some motion artefacts compared with accelerated scan pairs (p <= 0.001), which may influence the BSI. Subjects whose accelerated scans had significant motion had a higher mean vascular burden and age (p <= 0.05) whilst subjects whose non-accelerated scans had significant motion had poorer MMSE scores (p <= 0.05). No difference in estimated sample size requirements was found when using accelerated vs. non-accelerated scans. Accelerated scans reduce scan time and are better tolerated. Therefore it may be advantageous to use accelerated over non-accelerated scans in clinical trials that use ADNI-type protocols, especially in more cognitively impaired subjects.
机译：本研究的目的是评估加速MRI扫描是否代替非加速的扫描，影响了对照和受轻度认知障碍和Alzheimer疾病的控制和受试者的脑体积和萎缩率措施。我们在6个月的3个月和384名受试者中使用了861个受试者的数据，并在阿尔茨海默病神经影像倡议（ADNI）的12个月内。我们使用K-Means边界换档积分（BSI）计算了全脑，心室和海马萎缩速率。视觉评估扫描质量，良好质量的比例加速和非加速扫描比较。我们还将MMSE评分与质量差的扫描质量差的受试者之间进行了比较了MMSE评分，血管负荷和年龄。最后，我们在使用加速扫描和非加速扫描的萎缩率时估计假设临床试验的样本尺寸要求。在加速和非加速的扫描之间发现了全脑，心室和海马体积和萎缩率的显着差异。与加速扫描对（P <= 0.001）相比，至少一些运动人工的两倍于至少一些运动伪影（P <= 0.001），这可能影响BSI。加速扫描具有显着运动的受试者具有更高的平均血管负荷和年龄（P <= 0.05），而非加速扫描具有显着运动的受试者具有较差的MMSE评分（P <= 0.05）。在使用加速与非加速扫描时，发现估计的样本大小要求没有差异。加速扫描减少了扫描时间并更好地宽容。因此，在使用ADNI型方案的临床试验中，在使用ADNI型方案的临床试验中使用加速在非加速扫描中可能是有利的，特别是在更加认知的受试者中。

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