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首页> 外文期刊>Neurosurgical focus >Dabigatran, intracranial hemorrhage, and the neurosurgeon hemorrhage
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Dabigatran, intracranial hemorrhage, and the neurosurgeon hemorrhage

机译：Dabigatran，颅内出血和神经外科出血

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摘要

Dabigatran etexilate (Pradaxa) is a novel oral anticoagulant that has gained FDA approval for the prevention of ischemic stroke and systemic embolism in patients with nonvalvular atrial fibrillation. In randomized trials, the incidence of hemorrhagic events has been demonstrated to be lower in patients treated with dabigatran compared with the traditional anticoagulant warfarin. However, dabigatran does not have reliable laboratory tests to measure levels of anticoagulation and there is no pharmacological antidote. These drawbacks are challenging in the setting of intracerebral hemorrhage. In this article, the authors provide background information on dabigatran, review the existing anecdotal experiences with treating intracerebral hemorrhage related to dabigatran therapy, present a case study of intracranial hemorrhage in a patient being treated with dabigatran, and suggest clinical management strategies. The development of reversal agents is urgently needed given the growing number of patients treated with this medication.
机译：Dabigatran eTexilate（Pradaxa）是一种新的口服抗凝血剂，其在非瓣膜血管颤动患者中预防缺血性卒中和全身栓塞的批准。在随机试验中，与传统的抗凝血华法林相比，用达比甙治疗的患者的出血事件发生率降低。然而，Dabigatran没有可靠的实验室测试来测量抗凝水平，没有药理解毒剂。这些缺点在脑出血的设置中具有挑战性。在本文中，作者提供了关于Dabigatran的背景信息，审查与达比兰菌治疗有关的治疗脑出血的现有的轶事经验，目前患有达比甙治疗患者的颅内出血的病例研究，并提出了临床管理策略。促使逆转药剂的发展促使越来越多的患者患有这种药物治疗的患者。

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  • 来源
    《Neurosurgical focus》 |2013年第5期|共1页
  • 作者

    AwadA.J.; WalcottB.P.; StapletonC.J.; YanamadalaV.; NahedB.V.; CoumansJ.V.;

  • 作者单位

    Faculty of Medicine and Health Sciences An-Najah National University Nablus West Bank Palestine;

    Department of Neurosurgery Massachusetts General Hospital Harvard Medical School Boston MA;

    Department of Neurosurgery Massachusetts General Hospital Harvard Medical School Boston MA;

    Department of Neurosurgery Massachusetts General Hospital Harvard Medical School Boston MA;

    Department of Neurosurgery Massachusetts General Hospital Harvard Medical School Boston MA;

    Department of Neurosurgery Massachusetts General Hospital Harvard Medical School Boston MA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 外科学;
  • 关键词

    Dabigatran etexilate; Decompressive craniectomy; Fatal outcome; Pradaxa; Stroke; Tracheostomy; Warfarin;

    机译：Dabigatran eDexilate;减压颅骨切除术;致命结果;普拉德纳;中风;气管造口术;华法林;

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