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H2B ubiquitination: Conserved molecular mechanism, diverse physiologic functions of the E3 ligase during meiosis

机译：H2B泛素：守恒的分子机制，Meiosis期间E3连接酶的不同生理功能

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摘要

RNF20/Bre1 mediated H2B ubiquitination (H2Bub) has various physiologic functions. Recently, we found that H2Bub participates in meiotic recombination by promoting chromatin relaxation during meiosis. We then analyzed the phylogenetic relationships among the E3 ligase for H2Bub, its E2 Rad6 and their partner WW domain-containing adaptor with a coiled-coil (WAC) or Lge1, and found that the molecular mechanism underlying H2Bub is evolutionarily conserved from yeast to mammals. However, RNF20 has diverse physiologic functions in different organisms, which might be caused by the evolutionary divergency of their domain/motif architectures. In the current extra view, we not only elucidate the evolutionarily conserved molecular mechanism underlying H2Bub, but also discuss the diverse physiologic functions of RNF20 during meiosis.
机译：RNF20 / BRE1介导的H2B泛素化（H2BUB）具有各种生理功能。 最近，我们发现H2BUB通过在减数分裂期间促进染色质弛豫来参与减数分裂重组。 然后，我们用卷轴 - 线圈（WAC）或LGE1分析H2BUB，其E2 RAG6及其伴侣WW结构域的适配器的E3连接酶之间的系统发育关系，发现下面的H2BUB下面的分子机制从酵母中排出保留到哺乳动物 。 然而，RNF20在不同的生物体中具有不同的生理功能，这可能是由其域/主题架构的进化偏差引起的。 在目前的额外观点中，我们不仅阐明了H2BUB的进化保守的分子机制，还讨论了在减数分裂期间RNF20的不同生理功能。

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  • 来源
    《Nucleus》 |2017年第5期|共8页
  • 作者

    Wang Liying; Cao Chunwei; Wang Fang; Zhao Jianguo; Li Wei;

  • 作者单位

    Chinese Acad Sci Inst Zool State Key Lab Stem Cell &

    Reprod Biol Beijing Peoples R China;

    Chinese Acad Sci Inst Zool State Key Lab Stem Cell &

    Reprod Biol Beijing Peoples R China;

    Chinese Acad Sci Inst Zool State Key Lab Stem Cell &

    Reprod Biol Beijing Peoples R China;

    Chinese Acad Sci Inst Zool State Key Lab Stem Cell &

    Reprod Biol Beijing Peoples R China;

    Chinese Acad Sci Inst Zool State Key Lab Stem Cell &

    Reprod Biol Beijing Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    evolution; H2B ubiquitination; meiosis; phylogenetic analysis; RNF20;

    机译：进化;H2B泛素;MeIosis;系统发育分析;RNF20;

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