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首页> 外文期刊>Nutrition >Genetic variants in desaturase gene, erythrocyte fatty acids, and risk for type 2 diabetes in Chinese Hans
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Genetic variants in desaturase gene, erythrocyte fatty acids, and risk for type 2 diabetes in Chinese Hans

机译：遗传变异在去饱和酶基因，红细胞脂肪酸和中国汉斯中2型糖尿病的风险

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摘要

Objective: The aim of this study was to examine the association of the genetic variants in the fatty acid desaturase (FADS) gene cluster with erythrocyte phospholipid fatty acids (PLFA), and their relation to risk for type 2 diabetes mellitus (T2DM) in Han Chinese. Methods: Seven hundred and fifty-eight patients with T2DM and 400 healthy individuals were recruited. The erythrocyte PLFA and single-nucleotide polymorphism were determined by standard method. Results: Minor allele homozygotes and heterozygotes of rs174575 and rs174537 had lower PL 20:4 ω-6 levels in healthy individuals. Minor allele homozygotes and heterozygotes of rs174455 in FADS3 gene had lower levels of 22:5 ω-3, 20:4 ω-6, and δ5desaturase activity in patients with T2DM. Erythrocyte membrane PL 18:3 ω-3 (.P for trend = 0.002), 22:5 ω-3 (.P for trend < 0.001), ω-3 polyunsaturated fatty acid (.P for trend <0.001), and ω-3:ω-6 (.P for trend <0.001) were significantly inversely associated with risk for T2DM. Conclusion: Genetic variants in the FADS gene cluster are associated with altered erythrocyte PLFAs. High levels of PL 18:3 ω-3, 22:5 ω-3, and total ω-3 polyunsaturated fatty acid were associated with low risk for T2DM.
机译：目的：本研究的目的是检查脂肪酸去饱和酶（FADS）基因簇中的遗传变异与红细胞磷脂脂肪酸（PLFA）的遗传变体，及其与汉族2型糖尿病（T2DM）的风险的关系中国人。方法：招募了七百五十八名T2DM和400名健康个体患者。通过标准方法测定红细胞PLFA和单核苷酸多态性。结果：Rs174575和RS174537的次份纯合蛋白和杂合子具有下PL 20：4Ω-6水平的健康个体。 FADS3基因中RS174455的次要等位基因纯合蛋白和杂合子在T2DM患者中具有较低的22：5Ω-3,20：4Ω-6和Δ5Desaturarease活性。红细胞膜P18：3Ω-3（趋势= 0.002），22：5Ω-3（趋势<0.001），ω-3多不饱和脂肪酸（趋势<0.001），ω-3 -3：ω-6（趋势<0.001）显着与T2DM的风险有显着与风险相反。结论：FADS基因簇中的遗传变异与改变的红细胞PLFA相关。高水平的P18：3Ω-3,22：5Ω-3和总ω-3多不饱和脂肪酸与T2DM的低风险相关。

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  • 来源
    《Nutrition》 |2014年第8期|共6页
  • 作者

    HuangT.; SunJ.; ChenY.; XieH.; XuD.; HuangJ.; LiD.;

  • 作者单位

    Department of Food Science and Nutrition Zhejiang University Hangzhou China Department of;

    Clinical Nutrition Center Huadong Hospital Fudan University Shanghai China;

    Clinical Nutrition Center Huadong Hospital Fudan University Shanghai China;

    Clinical Nutrition Center Huadong Hospital Fudan University Shanghai China;

    Clinical Nutrition Center Huadong Hospital Fudan University Shanghai China;

    Department of Biostatistics Harvard School of Public Health Boston MA United States;

    Department of Food Science and Nutrition Zhejiang University Hangzhou China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 营养卫生、食品卫生;
  • 关键词

    Fatty acid desaturase; Phospholipids; Single-nucleotide polymorphism; Type 2 diabetes;

    机译：脂肪酸去饱和酶;磷脂;单核苷酸多态性;2型糖尿病;

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