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首页> 外文期刊>Nutrition & Food Science >The effect of fermented goat milk (kefir) fortified with vitamin D3 on total leukocyte levels in diabetic Rattus norvegicus rats
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The effect of fermented goat milk (kefir) fortified with vitamin D3 on total leukocyte levels in diabetic Rattus norvegicus rats

机译：发酵的山羊牛奶（Kefir）的作用强化维生素D3在糖尿病rattvicus大鼠的全白细胞水平上

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Purpose - Hyperglycemia in type 2 diabetes mellitus increases inflammation through pancreatic beta-cell destruction. Goat milk (kefir) and vitamin D3 have antioxidant and anti-inflammatory properties that can reduce pancreatic beta cells. Increase intotal leukocyte count is one of the inflammatory and complication markers of diabetes. This study aims to analyze the effect of fermented goat milk (kefir) fortified with vitamin D3 on total leukocyte counts in diabetic brown rat (Rattus norvegicus).Design/methodology/approach - An experimental design with pre- and post-test methodology of control and experimental groups was used. A total of 24 male Wistar rats were divided into four groups: negative control (K-), positive control (K+), kefir treatment (PI) and kefir fortified with vitamin D3 treatment (P2). The control group consisted of healthy rats; the other groups consisted of rats which were given streptozotocin-nicotinamide injections. Before and after intervention, fasting blood glucose levels and total leukocytes counts were measured. Blood glucose levels were analyzed using the GOD-PAP method and leukocyte counts were analyzed using an automatic hematological analyzer.Findings - There was a significant decrease in total leukocyte counts in the P2 group (from 26.5 ± 7.7 to 20.4 ± 10.4 [p < 0.05]). However, the decrease in leukocyte count in thePl group was not significant (from 22.1 ± 9.3 to 16.5 ± 6.2). The decrease in blood glucose levels in theP2 group was -81.4 ± 203.0 but not significant.Originality/value - Kefir with vitamin D3 fortification can significantly reduce total leukocyte counts in diabetes.
机译：目的 - 2型糖尿病中的高血糖症通过胰腺β细胞破坏增加炎症。山羊牛奶（Kefir）和维生素D3具有可减少胰腺β细胞的抗氧化剂和抗炎性质。增加型白细胞计数是糖尿病的炎症和并发症标志物之一。本研究旨在分析与维生素D3强化的发酵山羊牛奶（Kefir）对糖尿病γ（Rattus Norvegicus）的总白细胞计数的影响.Design /方法/方法 - 一种实验设计，具有控制前后的控制方法。使用实验组。将24只雄性Wistar大鼠分为四组：阴性对照（k-），阳性对照（k +），kefir治疗（pi）和kefir与维生素d3处理强化（p2）。对照组由健康的大鼠组成;其他基团由给予链脲佐菌素 - 烟酰胺注射的大鼠组成。在干预之前和之后，测量空腹血糖水平和总白细胞计数。使用全身血液分析仪分析血糖水平，使用自动血液学分析仪进行白细胞计数。P2组中的白细胞计数总体细胞计数显着降低（从26.5±7.7至20.4±10.4 [P <0.05 ]）。然而，白细胞计数下的白细胞计数下降不显着（从22.1±9.3至16.5±6.2）。 THEP2组血糖水平的降低为-81.4±203.0但不显着。乙酸维生素D3的葡萄球菌 - Kefir可以显着减少糖尿病中的全白细胞计数。

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