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首页> 外文期刊>Nitric oxide: Biology and chemistry >A randomized pilot study of nitrate supplementation with beetroot juice in acute respiratory failure
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A randomized pilot study of nitrate supplementation with beetroot juice in acute respiratory failure

机译:抗甜菜汁在急性呼吸衰竭中的硝酸盐补充剂的随机试验研究

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Nitrate rich beetroot juice (BRJ) can enhance nitric oxide signaling, leading to improved physical function in healthy and diseased populations, but its safety and biologic efficacy have not been evaluated in a critically ill population. We randomized 22 previously functional acute respiratory failure patients to either BRJ or placebo daily until day 14 or discharge. We measured blood nitrate and nitrite levels and quantified strength and physical function at intensive care unit (ICU) and hospital discharge. Participants were predominantly male (54%), aged 68.5 years with an APACHE III score of 62. BRJ increased plasma nitrate (mean 219.2 mu M increase, p = 0.002) and nitrite levels (mean 0.144 mu M increase, p = 0.02). We identified no adverse events. The unadjusted and adjusted effect sizes of the intervention on the short physical performance battery were small (d = 0.12 and d = 0.17, respectively). In this pilot trial, administration of BRJ was feasible and safe, increased blood nitrate and nitrate levels, but had a small effect on physical function. Future studies could evaluate the clinical efficacy of BRJ as a therapy to improve physical function in survivors of critical illness.
机译:富含甜菜根汁(BRJ)可以增强一氧化氮信号,导致健康和患病群体的物理功能改善,但其安全性和生物学疗效尚未在批评性群体中进行评估。我们将22例在第14天或放电之前将22例预先用作BRJ或安慰剂。我们测量血液硝酸盐和亚硝酸盐水平,并在重症监护室(ICU)和医院放电的定量强度和物理功能。参与者主要是雄性(54%),年龄为68.5岁,Apache III得分为62分。BRJ增加血浆硝酸盐(平均增加,P = 0.002)和亚硝酸盐水平(平均增加,P = 0.02)。我们确定没有不良事件。在短物理性能电池上的介入的未调整和调整的效果大小分别小(D = 0.12和D = 0.17)。在该试验试验中,BRJ的给药是可行和安全,血液血液和硝酸盐水平的可行性,增加,但对物理功能有很小影响。未来的研究可以评估BRJ作为治疗的临床疗效,以改善危重疾病幸存者中的物理功能。

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