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首页> 外文期刊>Nitric oxide: Biology and chemistry >Gender differences in the relationships between chronic kidney disease, asymmetric dimethylarginine, and sleep quality: The HEIJO-KYO cohort
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Gender differences in the relationships between chronic kidney disease, asymmetric dimethylarginine, and sleep quality: The HEIJO-KYO cohort

机译：慢性肾病，不对称二甲基碱与睡眠质量之间关系的性别差异：Heijo-Kyo Cohort

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The association between chronic kidney disease (CKD), serum levels of asymmetric dimethylarginine (ADMA), and sleep quality has not been studied in large populations. In this cross-sectional study of 1115 elderly individuals (mean age, 71.9 years), we measured serum levels of ADMA, and objective and subjective sleep quality using actigraphy and a standardized self-reported questionnaire, respectively. Multivariable analysis adjusted for potential confounders revealed that in females, compared with the non-CKD/low-ADMA group (n = 312), sleep efficiency was significantly lower in the CKD/high-ADMA group (n = 52) by 3.5% for objective sleep quality [95% confidence interval (CI), 1.1-5.9] and by 4.2% (95% CI, 0.3-8.0) for subjective sleep quality but not in the non-CKD/high-ADMA (n = 179) and CKD/low-ADMA (n = 36) groups. In males, no significant associations between CKD, ADMA levels, and sleep quality were observed. Wake time after sleep onset was significantly longer by 11.3 min (95% CI, 3.0-19.6) for objective sleep quality and by 25.9 min (95% CI, 4.9-46.9) for subjective sleep quality in the CKD/high-ADMA group than in the non-CKD/low-ADMA group in females but not in males. Mediation analysis revealed a significant effect of serum ADMA levels on the association between renal function and parameters of sleep quality among females. In conclusions, both objective and subjective sleep quality were poorer in elderly females with CKD/high-ADMA than in those with non-CKD/low-ADMA, but not in males. Association between CKD and sleep disturbances might be mediated by ADMA levels.
机译：慢性肾疾病（CKD），血清血清水平的不对称二甲基尿苷（ADMA）之间的关联尚未在大群中进行睡眠状态。在对1115名老年人（平均年龄，71.9岁）的横断面研究中，我们测量了Adma的血清水平，以及使用Atighaphy和标准化的自我报告的问卷的客观和主观睡眠质量。对潜在混凝器进行调整的多变量分析显示，与非CKD /低ADMA组（n = 312）相比，CKD /高ADMA组（n = 52）的睡眠效率明显低3.5％客观睡眠质量[95％置信区间（CI），1.1-5.9]和4.2％（95％CI，0.3-8.0），用于主观睡眠质量，但不在非CKD / HIGH-ADMA（N = 179）中CKD / Low-ADMA（n = 36）组。在雄性中，观察到CKD，ADMA水平和睡眠质量之间没有显着的关联。睡眠后的唤醒时间明显更长11.3分钟（95％CI，3.0-19.6），用于客观睡眠质量和25.9分钟（95％CI，4.9-46.9），用于CKD /高adma集团的主观睡眠质量在女性的非CKD /低adma组中，但不在男性中。调解分析显示血清ADMA水平对女性睡眠质量参数的显着影响。在结论中，客观和主观睡眠质量均较较差的老年女性，CKD /高adma比在非CKD / Low-Adma的人中，但不在男性中。 CKD和睡眠障碍之间的关联可能会被ADMA水平介导。

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