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首页> 外文期刊>Nitric oxide: Biology and chemistry >Nitric oxide releasing two-part creams containing S-nitrosoglutathione and zinc oxide for potential topical antimicrobial applications
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Nitric oxide releasing two-part creams containing S-nitrosoglutathione and zinc oxide for potential topical antimicrobial applications

机译：用于释放含有S-亚硝基葡萄脂素和氧化锌的两部分乳膏用于潜在的局部抗微生物应用

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摘要

Currently, most antimicrobial topical treatments utilize antibiotics to prevent or treat infection at a wound site. However, with the ongoing evolution of multi-drug resistant bacterial strains, there is a high demand for alternative antimicrobial treatments. Nitric oxide (NO) is an endogenous gas molecule with potent antimicrobial activity, which is effective against a wide variety of bacterial strains. In this study, the potential for creating NO releasing creams containing the naturally occurring NO carrier, S-nitrosoglutathione (GSNO), are characterized and evaluated. GSNO is shown to have prolonged stability (> 300 days) when mixed and stored within Vaseline at 24 degrees C. Further, enhanced proliferation of NO from GSNO using zinc oxide nanoparticles (ZnO) is demonstrated. Triggering NO release from the GSNO/Vaseline mixture using a commercial zinc oxide-containing cream exhibits first-order NO release kinetics with the highest %NO release over the first 6 h. Significant killing effects against S. aureus, S. epidermidis, and P. aeruginosa are demonstrated for the GSNO/Vaseline/ZnO cream mixtures in a proportional manner dependent upon the concentration of GSNO in the final mixture.
机译：目前，大多数抗菌局部治疗利用抗生素来预防或治疗伤口部位的感染。然而，随着多种耐药细菌菌株的持续发展，对替代抗微生物治疗的需求很大。一氧化氮（NO）是具有有效的抗微生物活性的内源性气体分子，其针对各种细菌菌株有效。在本研究中，表征和评估了产生含有天然存在的载体的含有天然存在的载体的释放面霜的释放乳膏的可能性。当混合并储存在24℃时，GSNO显示延长稳定性（> 300天）。进一步地，证明了使用氧化锌纳米颗粒（ZnO）的GSNO增强的NO增强。使用商业氧化锌的氧化锌乳膏触发从GSNO /凡士林混合物释放表现出一定一定的没有释放动力学，最高百分比没有释放到前6小时。针对S.UUREUS，S.表皮和P.铜绿假单胞菌的显着杀伤作用以比例方式对GSNO / vaseline / ZnO奶油混合物证明了GSNO / Vaseline / ZnO乳霜混合物，取决于最终混合物中的GSNO浓度。

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