Nitrite pharmacokinetics, safety and efficacy after experimental ventricular fibrillation cardiac arrest

Uray Thomas; Empey Philip E.; Drabek Tomas; Stezoski Jason P.; Janesko-Feldman Keri; Jackson Travis; Garman Robert H.; Kim Francis; Kochanek Patrick M.; Dezfulian Cameron

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Nitrite pharmacokinetics, safety and efficacy after experimental ventricular fibrillation cardiac arrest

机译：实验性心脏颤动后亚硝酸盐药代动力学，安全性和疗效心脏骤停

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Introduction: Besides therapeutic hypothermia or targeted temperature management no novel therapies have been developed to improve outcomes of patients after cardiac arrest (CA). Recent studies suggest that nitrite reduces neurological damage after asphyxial CA. Nitrite is also implicated as a new mediator of remote post conditioning produced by tourniquet inflation-deflation, which is under active investigation in CA. However, little is known about brain penetration or pharmacokinetics (PK). Therefore, to define the optimal use of this agent, studies on the PK of nitrite in experimental ventricular fibrillation (VF) are needed. We tested the hypothesis that nitrite administered after resuscitation from VF is detectable in cerebrospinal fluid (CSF), brain and other organ tissues, produces no adverse hemodynamic effects, and improves neurologic outcome in rats.

机译：介绍：除了治疗性低温还是有针对性的温度管理外，没有开发出新的疗法，以改善心脏骤停（CA）后患者的结果。最近的研究表明，亚硝酸亚硝酸盐在窒息CA后降低了神经损伤。亚硝酸盐也被牵连作为止血带通胀通胀产生的遥控后调节的新介质，这是在CA的积极调查下。但是，关于脑渗透或药代动力学（PK）很少。因此，为了定义该试剂的最佳用途，需要对实验性心室纤维化（VF）中亚硝酸盐的PK的研究。我们测试了在脑脊液（CSF）中可检测到VF后施用亚硝酸盐在脑脊液（CSF），脑和其他器官组织中进行的假设，不会产生不良血液动力学效应，并改善大鼠的神经系统结果。

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《Nitric oxide: Biology and chemistry》 |2019年第2019期|共7页
作者
Uray Thomas; Empey Philip E.; Drabek Tomas; Stezoski Jason P.; Janesko-Feldman Keri; Jackson Travis; Garman Robert H.; Kim Francis; Kochanek Patrick M.; Dezfulian Cameron;
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作者单位

Univ Pittsburgh Sch Med Safar Ctr Resuscitat Res Pittsburgh PA USA;

Univ Pittsburgh Sch Med Safar Ctr Resuscitat Res Pittsburgh PA USA;

Univ Pittsburgh Sch Med Safar Ctr Resuscitat Res Pittsburgh PA USA;

Univ Pittsburgh Sch Med Safar Ctr Resuscitat Res Pittsburgh PA USA;

Univ Pittsburgh Sch Med Safar Ctr Resuscitat Res Pittsburgh PA USA;

Univ Pittsburgh Sch Med Safar Ctr Resuscitat Res Pittsburgh PA USA;

Univ Pittsburgh Dept Pathol Pittsburgh PA USA;

Univ Washington Harborview Med Ctr Dept Med Seattle WA 98104 USA;

Univ Pittsburgh Sch Med Safar Ctr Resuscitat Res Pittsburgh PA USA;

Univ Pittsburgh Sch Med Safar Ctr Resuscitat Res Pittsburgh PA USA;

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正文语种 eng
中图分类第Ⅴ族元素及其化合物;生物物理学;
关键词
Heart arrest; Cardiopulmonary resuscitation; Animals; Laboratory; Ventricular fibrillation; Asphyxia;

机译：心脏骤停;心肺复苏;动物;实验室;心室颤动;窒息;

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1. Nitrite pharmacokinetics, safety and efficacy after experimental ventricular fibrillation cardiac arrest [J] . Uray Thomas, Empey Philip E., Drabek Tomas, Nitric oxide: Biology and chemistry . 2019,第期

机译：实验性心脏颤动后亚硝酸盐药代动力学，安全性和疗效心脏骤停
2. Safety and efficacy of landiolol hydrochloride for prevention of atrial fibrillation after cardiac surgery in patients with left ventricular dysfunction: Prevention of Atrial Fibrillation After Cardiac Surgery With Landiolol Hydrochloride for Left Ventricular Dysfunction (PLATON) trial [J] . Sezai Akira, Osaka Shunji, Yaoita Hiroko, The Journal of Thoracic and Cardiovascular Surgery . 2015,第4期

机译：左心室功能障碍患者心脏手术治疗心房手术后LANDIOLOL盐酸盐的安全性和有效性：心脏手术治疗左心室功能障碍（谷仓）试验后心脏手术后心房颤动
3. Safety and efficacy of landiolol hydrochloride for prevention of atrial fibrillation after cardiac surgery in patients with left ventricular dysfunction: Prevention of Atrial Fibrillation After Cardiac Surgery With Landiolol Hydrochloride for Left Ventricular Dysfunction (PLATON) trial [J] . Akira Sezai, Shunji Osaka, Hiroko Yaoita, The journal of thoracic and cardiovascular surgery . 2015,第4期

机译：盐酸兰地洛尔预防左心功能不全患者心脏手术后房颤的安全性和有效性：盐酸兰地洛尔用于左心功能不全的心脏手术后预防心房颤动的试验
4. Classification of asphyxia ventricular fibrillation induced cardiac arrest for cardiopulmonary resuscitation [C] . Dieter Bender, Ryan W. Morgan, Vinay M. Nadkarni, 2017 IEEE Healthcare Innovations and Point of Care Technologies . 2017

机译：窒息和心室纤颤诱发的心脏骤停的分类，用于心肺复苏
5. The link between metabolic stress and electrical failure in a model of ventricular fibrillation induced sudden cardiac arrest [D] . Taylor, Tyson G. 2014

机译：在心室纤颤诱发的突发性心脏骤停模型中，代谢应激与电衰竭之间的联系
6. The dynamic pattern of end-tidal carbon dioxide during cardiopulmonary resuscitation: difference between asphyxial cardiac arrest and ventricular fibrillation/pulseless ventricular tachycardia cardiac arrest [O] . Katja Lah, Miljenko Križmarić, Štefek Grmec 2011

机译：心肺复苏过程中潮气末二氧化碳的动态模式：窒息性心脏骤停与室颤/无脉性室性心动过速心脏骤停之间的差异
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Nitrite pharmacokinetics, safety and efficacy after experimental ventricular fibrillation cardiac arrest

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