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首页> 外文期刊>Nitric oxide: Biology and chemistry >Permeability and diffusivity of nitric oxide in human plasma and red cells
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Permeability and diffusivity of nitric oxide in human plasma and red cells

机译：人血浆和红细胞中一氧化氮的渗透性和扩散性

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A simple diffusion cell was made to measure the permeability and diffusivity of Nitric Oxide in human plasma and red cells. Nitric oxide was passed through the cell containing plasma or nitrited red cells enclosed by silicone membranes. Steady state permeability (alpha D-NO(NO)) was calculated from the cell dimensions and from the NO bulk flow entering and leaving the cell. The diffusion coefficient (D-NO) was calculated in three ways: (i) by dividing the steady state permeability by published values for solubility (alpha(NO)) in water at 26 degrees C and 37 degrees C (ii) by a numerical method and (iii) by an analytical method. Mean steady state permeability (95% confidence intervals) were plasma (26 degrees C) 5.57 x 10(-11) (2.35 x 10(-11)-1.32 x 10(-1)) and (37 degrees C) 5.48 x 10(-11) (2.13 x 10(-11)-1.41 x 10(-10)) mol cm(-1) s(-1) atm(-1) and red cells (26 degrees C) 6.74 x 10(-12) (1.29 x 10(-12)-3.53 x 10(-11)) and (37 degrees C) 3.93 x 10(-11) (1.39 x 10(-11)-1.11.10(-1)) mol cm(-1) s(-1) atm(-1). Median Diffusion Coefficients (D-NO) for plasma at 37 degrees C ranged from 3-3.36 x 10(-5) cm(2) s(-1) and red cells 2.41-2.94 x 10(-5) cm(2) s(-1) depending on the method used. These values may be used for modelling NO transport in vivo in the human lung and capillary. Parameters used for modelling in vivo should be measured at 37 degrees C.
机译：制备简单的扩散电池以测量人血浆和红细胞中一氧化氮的渗透率和扩散性。通过含有由硅氧烷膜包围的含有血浆或硝基红色细胞的细胞来通过一氧化物。从细胞尺寸和从进入和离开细胞的没有散装流量计算稳态渗透率（αd-no（no））。通过三种方式计算扩散系数（D-No）：（i）通过在26℃和37℃（II）的水中在水中的溶解度（α（NO））的公开值除以稳态渗透性方法和（III）通过分析方法。平均稳态渗透率（95％置信区间）是等离子体（26℃）5.57×10（-11）（2.35×10（-11）-1.32×10（-1））和（37℃）5.48 x 10 （-11）（2.13×10（-11）-1.41 x 10（-10））mol cm（-1）s（-1）atm（-1）和红色细胞（26℃）6.74 x 10（ - 12）（1.29×10（-12）-3.53×10（-11））和（37℃）3.93×10（-11）（1.39×10（-11）-1.11.10（-1））mol cm（-1）s（-1）atm（-1）。 37摄氏度的等离子体中值扩散系数（D-No）范围为3-3.36×10（-5）cm（2）s（-1）和红色细胞2.41-2.94×10（-5）cm（2） s（-1）取决于所使用的方法。这些值可用于在人肺和毛细管中的体内进行建模。用于在体内建模的参数应在37摄氏度下测量。

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