...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BJU international >Muscle-invasive bladder cancer: Evaluating treatment and survival in the National Cancer Data Base
【24h】

Muscle-invasive bladder cancer: Evaluating treatment and survival in the National Cancer Data Base

机译：肌肉浸润性膀胱癌：在国家癌症数据库中评估治疗和生存

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective To evaluate the association between patterns of care and patient survival for the treatment of muscle-invasive bladder cancer (MIBC) using a large, national database. Patients and Methods We identified a cohort of 36 469 patients with MIBC (stage II) from 1998 to 2010 from the National Cancer Data Base. Patients were stratified into four treatment groups: radical cystectomy, chemo-radiation, other therapy, or no treatment. Overall survival (OS) among the groups was evaluated using Kaplan-Meier analysis and the log rank test. A multivariable Cox proportional hazards model was fit to evaluate the association between treatment groups and OS. Results In all, 27% of patients received radical cystectomy, 10% chemo-radiation, 61% other therapy and 2% no treatment. Unadjusted Kaplan-Meier analysis showed significant differences by treatment group, with cystectomy having the greatest median OS (48 months) followed by chemo-radiation (28 months), other therapy (20 months), and no treatment (5 months). When controlling for multiple covariates, the OS for cystectomy was similar to that for chemo-radiation (hazard ratio [HR] 1.05, 95% confidence interval [CI] 0.98, 1.12), but superior to other therapy (HR 1.42; 95% CI 1.35, 1.48), and no treatment (HR 2.40; 95% CI 2.12, 2.72). The OS time for chemo-radiation was superior to other therapy and no treatment. Conclusions Radical cystectomy and chemo-radiation are significantly underused despite a substantial survival benefit compared with other therapies or no treatment. Future studies are needed to optimise care delivery and improve outcomes for patients with MIBC.
机译：目的使用大型的国家数据库评估治疗模式与患者生存率之间的联系，以治疗肌肉浸润性膀胱癌（MIBC）。患者和方法我们从美国国家癌症数据库中确定了1998年至2010年的36469例MIBC（II期）患者。将患者分为四个治疗组：根治性膀胱切除术，化学放疗，其他治疗或不治疗。使用Kaplan-Meier分析和对数秩检验评估各组之间的总生存（OS）。拟合多变量Cox比例风险模型以评估治疗组和OS之间的关联。结果总共有27％的患者接受了根治性膀胱切除术，10％的化学放射治疗，61％的其他治疗和2％的未治疗。未经调整的Kaplan-Meier分析显示各治疗组之间存在显着差异，膀胱切除术的中位OS最大（48个月），其次是化学放疗（28个月），其他疗法（20个月）和无治疗（5个月）。当控制多个协变量时，膀胱切除术的OS与化学放射治疗相似（危险比[HR] 1.05，95％置信区间[CI] 0.98，1.12），但优于其他疗法（HR 1.42; 95％CI） 1.35、1.48）和不接受治疗（HR 2.40; 95％CI 2.12，2.72）。化学放疗的OS时间优于其他治疗且无治疗。结论与其他疗法或不进行任何治疗相比，根治性膀胱切除术和化学放射疗法尽管具有显着的生存获益，但仍未得到充分利用。需要进一步的研究来优化MIBC患者的护理服务并改善其结局。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号