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首页> 外文期刊>Lung cancer: Journal of the International Association for the Study of Lung Cancer >Different histological subtypes of peripheral lung cancer based on emphysema distribution in patients with both airflow limitation and CT-determined emphysema
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Different histological subtypes of peripheral lung cancer based on emphysema distribution in patients with both airflow limitation and CT-determined emphysema

机译：基于气流限制和CT确定肺气肿的肺气肿分布的基于肺气肿分布的外周肺癌不同的组织学亚型

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The histological subtypes by peripheral tumor location remain uncharacterized in COPD patients with emphysema. We investigated histologic subtypes of peripheral lung cancers based on the context of heterogeneous emphysema distribution in patients with airflow limitation and CT-determined emphysema. A retrospective, cross-sectional study was conducted using data from 754 patients with airflow limitation and newly-diagnosed primary lung cancers from February 2013 to February 2015. Of these, 230 patients had emphysema, as determined by computed tomography software designed to quantify emphysema. Among the 230 patients, the most common subtype in central lesions (n=84) was squamous cell carcinoma (SCC) (n = 64/84, 76%). Adenocarcinoma (ADC) was more frequently observed in peripheral lesions (n=146) than central lesions (58/146 [40%] vs. 4/84 [5%], p < 0.001). In peripheral lesions, ADC was more frequently seen in areas without emphysema than emphysema areas (43/74 [58%] vs. 15/72 [21%], p < 0.001), while SCC was more frequently found in emphysema areas than areas without emphysema (44/72 [61%] vs. 13/74[18%], p < 0.001). These associations persisted with adjustments for age, sex, smoking status and forced expiratory volume in 1 s. In patients with both airflow limitation and CT-determined emphysema, the main histological subtype of peripheral lung cancer was SCC in emphysema areas and ADC in areas without emphysema. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
机译：外周肿瘤位置的组织学亚型在肺气肿的COPD患者中保持不表达。我们根据气流限制患者的异质肺气肿分布和CT确定的肺气肿，研究了外周血肺癌的组织学亚型。通过从754例气流限制和2013年2月到2015年2月的新诊断的原发性肺癌进行了回顾性的横截面研究。其中230名患者具有肺气肿，由旨在量化肺气肿的计算机断层扫描软件。在230名患者中，中央病变中最常见的亚型（n = 84）是鳞状细胞癌（SCC）（n = 64/84,76％）。在外周病变（n = 146）中比中央病变更常见的腺癌（ADC）（58/146 [40％] Vs. 4/84 [5％]，P <0.001）。在外周病变中，ADC在没有肺气肿的区域中比肺气肿地区（43/74 [58％]，p <0.001），而SCC在肺气肿地区更常见的区域（43/74 [58％]，P <0.001）。没有肺气肿（44/72 [61％] vs.13 / 74 [18％]，P <0.001）。这些协会持续到1秒内的年龄，性别，吸烟状态和强制呼气量调整。在气流限制和CT确定的肺气肿患者中，外周血肺癌的主要组织学亚型在没有肺气肿的地区的肺气肿地区和ADC中是SCC。 （c）2016 Elsevier Ireland Ltd.保留所有权利。

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