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首页> 外文期刊>BJU international >Papillary renal cell carcinoma: clinicopathological characteristics and evaluation of prognosis in 42 patients.
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Papillary renal cell carcinoma: clinicopathological characteristics and evaluation of prognosis in 42 patients.

机译：乳头状肾细胞癌：42例临床病理特征及预后评估。

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OBJECTIVE: To determine the clinicopathological characteristics of histologically defined papillary renal cell carcinoma (RCC) in relation to prognosis. PATIENTS AND METHODS: In total, 768 patients with RCC underwent nephrectomy at our university hospital between 1957 and 1995. RCC was classified into clear-cell carcinoma in 689 patients (89.7%, no follow-up in 14), chromophobe cell carcinoma in 36 (4.7%, no follow-up in two) and papillary RCC in 43 (5.6%, no follow-up in one). In the present study, the 42 patients with papillary RCC who underwent nephrectomy and were followed up were those in whom the clinicopathological features of the papillary RCC were assessed. Factors assessed were the presence or absence of foam-cell infiltration, occurrence of bleeding and/or necrosis, presence or absence of a pseudocapsule, mixed occurrence with clear-cell carcinoma, presence or absence of solid variants, cytoplasmic appearance (basophilic vs eosinophilic cells), stage, nuclear grade of malignancy, and angiographic appearance in relation to prognosis. The prognosis was also compared among patients with clear-cell, chromophobe cell and papillary RCC. RESULTS: The prognosis was significantly better in patients with foam-cell infiltration (P=0.03), with a pseudocapsule (P=0.07), with no solid variants (P=0.001) and with basophilic cells (P<0.001). There were also significant differences in survival between patients with low-stage (1+2) and high-stage (3+4) disease (P=0.003), and among grades 1-3 (grade 1 vs 2, P=0.05; grade 1 vs 3, P<0.001, grade 2 vs 3, P=0.006). Furthermore, the prognosis in patients with papillary RCC was worse than in those with chromophobe cell carcinoma (P=0.02), but there was no significant difference in survival between patients with papillary RCC and those with clear-cell carcinoma. CONCLUSION: The clinicopathological features (e.g. the presence or absence of foam cells, of a pseudocapsule and of solid variants, cytoplasmic appearance, and the stage and nuclear grade of malignancy) are important prognostic factors for patients with papillary RCC. Furthermore, the prognosis in patients with papillary RCC is similar to those with clear-cell carcinoma.
机译：目的：确定组织学定义的乳头状肾细胞癌（RCC）的临床病理特征与预后的关系。患者与方法：1957年至1995年间，共768例RCC患者在我们的大学医院接受了肾切除术。RCC被分类为689例患者中的透明细胞癌（89.7％，未随访14例），发色细胞癌36例。 （4.7％，无随访），有43例（5.6％，无随访）。在本研究中，对42例接受了肾切除术并接受了随访的乳头状RCC患者进行了乳头状RCC的临床病理特征评估。评估的因素包括是否存在泡沫细胞浸润，是否存在出血和/或坏死，是否存在假胶囊，与透明细胞癌混合发生，是否存在固体变体，胞质外观（嗜碱性与嗜酸性细胞），分期，恶性程度，血管造影表现与预后有关。还比较了透明细胞，生色细胞和乳头状RCC患者的预后。结果：泡沫细胞浸润（P = 0.03），假胶囊（P = 0.07），无固体变体（P = 0.001）和嗜碱性细胞（P <0.001）的患者的预后明显好转。低度（1 + 2）和高度（3 + 4）疾病患者之间的生存率也存在显着差异（P = 0.003），并且1-3级患者之间的生存率也存在显着差异（1级vs 2，P = 0.05; 1年级vs 3，P <0.001，2年级vs 3，P = 0.006）。此外，乳头状RCC患者的预后要比发色细胞癌的患者差（P = 0.02），但乳头状RCC患者与透明细胞癌的患者生存率无显着差异。结论：临床病理特征（例如，是否存在泡沫细胞，假胶囊和固体变体，细胞质外观，恶性程度和核分级）是乳头状RCC患者的重要预后因素。此外，乳头状RCC患者的预后与透明细胞癌相似。

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