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首页> 外文期刊>BJU international >The long-term outcome in patients with superficial transitional cell carcinoma of the bladder: a single-institutional experience.
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The long-term outcome in patients with superficial transitional cell carcinoma of the bladder: a single-institutional experience.

机译：膀胱浅表移行细胞癌患者的长期结局：单机构经验。

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OBJECTIVE: To determine the natural history of transitional cell carcinoma (TCC) of the bladder, and to identify factors which place patients at lifelong risk of developing progression and dying from bladder carcinoma. PATIENTS AND METHODS: The long-term outcome was evaluated retrospectively in 231 patients with superficial bladder TCC, assessed for the first time within a 6-year period from 1981 to 1986, with a median follow-up of 108 months. Of 231 patients, 217 (94%) were initially treated by transurethral or segmental resection. RESULTS: Recurrence developed in 141 of 217 (65%) patients; the duration of the interval free of recurrence was significantly less for patients with initial G3 tumours than that for those with G1 (P<0.01) and for pT1 compared with pTa disease (P<0.01). The disease progressed in 42 of 231 (18%) patients. Differences in the progression-free interval between patients with G1 and G3 tumours, and with pTa and pT1 disease, were statistically significant (P<0. 005 and P<0.001, respectively). In 27 of 231 patients (12%), TCC of the bladder was the cause of death, whilst 118 (51%) died from unrelated causes. There were no deaths among patients with initial pTaG1 tumours, compared with 10 of 26 (38%) deaths in those with pT1G3 disease at presentation. CONCLUSION: The long-term prognosis is good for patients with pTaG1 tumours, whilst pT1G3 is a potentially aggressive disease. Lifelong endoscopic surveillance is mandatory in patients in whom new tumours are very active, at least in those of younger age. Routine cystoscopy can possibly be discontinued in patients with low-grade, low-stage disease in whom a low liability of recurrence has been shown during follow-up.
机译：目的：确定膀胱移行细胞癌（TCC）的自然病史，并确定使患者终生罹患膀胱癌发展和死亡的风险的因素。患者与方法：回顾性分析了231例浅表性TCC患者的长期预后，该患者在1981年至1986年的6年内首次进行评估，中位随访时间为108个月。在231例患者中，有217例（94％）最初通过经尿道或节段性切除术进行了治疗。结果：217例患者中有141例（65％）复发。与pTa病相比，G3初始肿瘤患者的无复发间隔时间明显少于G1肿瘤的患者（P <0.01）和pT1。该病在231例患者中有42例（18％）进展。 G1和G3肿瘤患者以及pTa和pT1疾病患者的无进展时间间隔差异具有统计学意义（分别为P <0.005和P <0.001）。在231例患者中，有27例（12％）膀胱TCC是死亡原因，而118例（51％）死于无关原因。最初患有pTaG1肿瘤的患者中无死亡病例，相比之下，患有pT1G3疾病的26例死亡中有10例（38％）死亡。结论：pTaG1肿瘤患者的长期预后良好，而pT1G3是一种潜在的侵袭性疾病。对于新肿瘤活跃的患者（至少在年轻患者中），必须进行终生内窥镜监测。对于低度，低分期疾病的患者，在随访期间表现出较低的复发风险时，可以停止常规膀胱镜检查。

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